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https://www.hindawi.com/journals/jir/2019/8303648/
1.8. The Intradermal Vaccine Delivery and Its Associated Immune Response. Another vaccine delivery route capable of triggering both systemic and mucosal immunities is the intradermal route, in which the antigen is delivered through the skin using recently developed self-administrable devices.Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.annualreviews.org/doi/abs/10.1146/annurev-bioeng-071811-150054
Efforts have focused on efficient delivery of vaccine antigens to mucosal sites that facilitate uptake by local antigen-presenting cells to generate protective mucosal immune responses. Discovery of safe and effective mucosal adjuvants are also being sought to enhance the magnitude and quality of the protective immune response.Author: Kim A. Woodrow, Kaila M. Bennett, David D. Lo
https://www.medscape.com/viewarticle/581891
Oct 18, 2019 · In this article, we summarize recent progress on oral vaccine delivery and explore the feasibility of such an approach to protect against diseases transmitted through non-mucosal routes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
Vaccine delivery systems can be classified as follows. Solid particulates: Solid particulate systems such as microspheres and lipospheres are being exploited for vaccine delivery [Table 1] based on the fact that intestine is an imperfect barrier to small particulates. Antigens entrapped in such particulates when taken up by M-cells can generate ...
https://www.sciencedirect.com/science/article/pii/B9780128119242000195
Mucosal Vaccine Delivery: Past, Present and Future A. Oral Vaccine Delivery. Gastrointestinal (GI) infection is a significant global health challenge, especially in developing countries. Most GI infections are spread via the fecal–oral route, primarily through contaminated water and food due to poor sanitation and social infrastructure.Author: Joon Haeng Rhee
https://www.ncbi.nlm.nih.gov/pubmed/26860287
Oct 28, 2016 · Thus, mucosal vaccination is highly appealing, especially for the pediatric population. However, vaccine delivery across mucosal surfaces is challenging because of the different barriers that naturally exist at the various mucosal surfaces to keep the pathogens out.Author: Akhilesh Kumar Shakya, Mohammed Y.E. Chowdhury, Wenqian Tao, Harvinder Singh Gill
https://www.sciencedirect.com/science/article/pii/S0168365914003861
Mucosal vaccine delivery in the mouth can be subdivided into sublingual and buccal delivery. Sublingual delivery occurs via the mucosa of the ventral surface of the tongue and the floor of the mouth under the tongue, whereas buccal delivery occurs via the buccal mucosa, which is located in the cheeks, the gums and the upper and lower inner lips (). ...Author: Heleen Kraan, Hilde Vrieling, Cecil Czerkinsky, Wim Jiskoot, Gideon Kersten, Jean-Pierre Amorij
https://www.immunology.org/public-information/bitesized-immunology/vaccines-and-therapeutics/mucosal-vaccination
Mucosal tissues (e.g. nasal, oral, ocular, rectal, vaginal) cover a large surface of the body. Since many infections are initiated at mucosal sites, it is critical to develop strategies for neutralising the infectious agent at these surfaces. Mucosal vaccination involves the administration of vaccines at one or more mucosal sites leading to induction of immune responses at the
https://www.medscape.com/viewarticle/766506_4
Nov 01, 2019 · Mostly using mouse models, potential mucosal adjuvants for intranasal vaccine delivery that have been tested include detoxified lipopolysaccharide, TLR9 agonist, immunostimulatory complexes, MF59 ...
https://www.hindawi.com/journals/jir/2016/5482087/
Thus, a successful mucosal vaccine must be capable of inducing not only an adaptive immune response, but also a strong innate immune response . Fortunately, liposomes can do both. They can both serve as delivery vehicles for vaccine antigens and act as immunomodulators, triggering both innate and adaptive immune responses.Author: Valentina Bernasconi, Karin Norling, Marta Bally, Fredrik Höök, Nils Y. Lycke
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