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https://www.annualreviews.org/doi/abs/10.1146/annurev-bioeng-071811-150054
Mucosal surfaces are a major portal of entry for many human pathogens that are the cause of infectious diseases worldwide. Vaccines capable of eliciting mucosal immune responses can fortify defenses at mucosal front lines and protect against infection.Author: Kim A. Woodrow, Kaila M. Bennett, David D. Lo
https://www.sciencedirect.com/science/article/pii/S0169409X06000068
The delivery of vaccines through the mucosal route is very practical, non-invasive and efficacious for the induction of mucosal and systemic immune responses. Appropriately formulated mucosal vaccines can stimulate all arms of the immune system and could be exploited for protection against pathogens that infect the host through the mucosal surfaces as well as those acquired through other routes.Author: Maria Teresa De Magistris
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896761/
Jul 21, 2014 · The mucosal immunity acquired by natural influenza infection, primarily due to the production of S-IgA in the respiratory tract, is more effective and cross-protective against subsequent viral infection than the systemic immunity induced by parenteral vaccines in humans and mice. 152 In agreement with this observation, many comparative studies of mucosal (i.n, rectal, oral) and …Author: Mevyn Nizard, Mariana O Diniz, Helene Roussel, Thi Tran, Luis Cs Ferreira, Cecile Badoual, Eric Tart...
http://www.eurekaselect.com/93874/article
Mucosal delivery of vaccine provides basis for induction of both mucosal as well as systemic immune responses against the infectious organisms. However, a variety of factors such as mucociliary clearance, presence of deteriorating enzymes, pH extremes (GIT), low permeation and metabolic degradation limit the mucosal delivery of vaccine.Author: Neeraj K. Garg, Sharad Mangal, Hemant Khambete, Pradeep K. Sharma, Rajeev K. Tyagi
https://www.sciencedirect.com/science/article/pii/S105046482030005X
Mucosal vaccines employed for humans and animals include oral, nasal, sublingual and genital tract vaccines, which have many advantages when compared to systemic vaccines in terms of means of delivery and stimulation of the immune system . Simple means of delivery which are needle-free administrations results in low stress for vaccine recipients and administrators.Author: Tomonori Somamoto, Teruyuki Nakanishi
https://www.hindawi.com/journals/jir/2019/8303648/
Another vaccine delivery route capable of triggering both systemic and mucosal immunities is the intradermal route, in which the antigen is delivered through the skin using recently developed self-administrable devices.Author: E. Criscuolo, V. Caputo, V. Caputo, R. A. Diotti, R. A. Diotti, G. A. Sautto, G. A. Kirchenbaum, N. ...
https://www.molecularvirology.org/PDF/Miquel-Clop%e9s%20et%20al%202019.pdf
availability of mucosal vaccines is related to the lack of effective delivery systems able to preserve vaccine antigen integrity and strong adjuvanticity, which is compounded by the intrinsic nature of the mucosal immune system
https://www.immunology.org/public-information/bitesized-immunology/vaccines-and-therapeutics/mucosal-vaccination
Mucosal vaccination involves the administration of vaccines at one or more mucosal sites leading to induction of immune responses at the Mucosal tissues (e.g. nasal, oral, ocular, rectal, vaginal) cover a large surface of the body.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
mucosal delivery of vaccines Mucosal vaccination offers protection against microorganisms which gain access to body via mucosal membranes. Patient compliance, ease of administration, reduction in possibility of needle-borne injections, stimulation of both systemic and mucosal …
https://www.medscape.com/viewarticle/581891
Oct 18, 2019 · The possibility of developing oral vaccines against non-mucosal pathogens is supported by studies with Japanese encephalitis and hepatitis B, which are transmitted by mosquito- …
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