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https://www.sciencedirect.com/science/article/pii/S0144861719311749
Furthermore, their mucoadhesive properties and the transient opening of tight junctions by chitosan could constitute a synergy for NPs to serve as vehicles for oral delivery of insulin-bypass GIT enzymes and allow prolonged release of insulin at the absorption site.Author: Momoh A. Mumuni, Franklin C. Kenechukwu, Kenneth C. Ofokansi, Anthony A. Attama, David Díaz Díaz, Da...
https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10015
Oral delivery of proteins such as insulin has been a long‐lasting challenge owing to gastrointestinal degradation and poor permeability of therapeutic macromolecules across biological membranes. We have developed mucoadhesive intestinal devices for oral delivery of insulin …Author: Amrita Banerjee, JooHee Lee, Samir Mitragotri
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322271/
May 01, 2012 · Consequently, mucoadhesive nanoparticles could have limitations for oral delivery, including the possibility of adhering nonspecifically to unintended surfaces. It is likely that rather than reaching the more slowly cleared firmly adherent mucus layer, mucoadhesive nanoparticles will become trapped in the loosely adherent mucus layer and become vulnerable to rapid clearance [ 42 ].Author: Laura M. Ensign, Laura M. Ensign, Richard Cone, Richard Cone, Justin Hanes
https://www.researchgate.net/publication/339634163_Mucoadhesive_Chitosan-Based_Nanoparticles_for_Oral_Drug_Delivery
Nanoparticles in particular show promise to facilitate targeted oral drug delivery in IBD. Here we discuss the pitfalls of current therapies and explore the potential for nanoparticles to improve ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744591/
Sep 12, 2019 · Surface-modified mucoadhesive microparticles as a controlled release system for oral delivery of insulin Momoh A. Mumuni , a, ∗ Frankilin C. Kenechukwu , a Omeje C. Ernest , a Adedokun M. Oluseun , b Barikisu Abdulmumin , c Darlington C. Youngson , a …Author: Momoh A. Mumuni, Frankilin C. Kenechukwu, Omeje C. Ernest, Adedokun M. Oluseun, Barikisu Abdulmumin,...
https://link.springer.com/article/10.1007/s11095-007-9367-4
Jun 19, 2007 · The results indicate that the encapsulation of insulin into mucoadhesive nanoparticles was a key factor in the improvement of its oral absorption and oral bioactivity. To evaluate the pharmacological activity of insulin-loaded alginate/chitosan nanoparticles following oral dosage in diabetic rats.Author: B. Sarmento, A. Ribeiro, F. Veiga, P. Sampaio, R. Neufeld, D. Ferreira
https://www.sciencedirect.com/science/article/pii/S0168365906005797
When administered orally by force-feeding to diabetic rats, insulin nanoparticles decreased fasted glycemia in a dose dependant manner with a maximal effect observed with 100 IU/kg. These insulin nanoparticles also increased serum insulin levels and improved the glycemic response to an oral glucose challenge for a prolonged period of time.Author: Christiane Damgé, Philippe Maincent, Nathalie Ubrich
https://www.nature.com/articles/s41551-019-0465-5
Anionic nanoparticles increase intestinal permeability and enable the oral delivery of proteins, as shown with the delivery of insulin in healthy, hyperglycaemic, and diabetic mice.Author: Nicholas G. Lamson, Adrian Berger, Katherine C. Fein, Kathryn A. Whitehead
https://link.springer.com/content/pdf/10.1007%2Fs11051-015-2909-5.pdf
Feb 20, 2015 · Development and evaluation of mucoadhesive nanoparticles based on thiolated Eudragit for oral delivery of protein drugs. Yan Zhang 1,2,3, Zhijie ... Du X, Tang X et al (2014) Thiolated Eudragit based nanoparticles for oral insulin delivery: preparation, characterization, and evaluation using intestinal epithelial cells in vitro. Macromol Biosci ...Author: Yan Zhang, Yan Zhang, Zhijie Yang, Xi Hu, Ling Zhang, Feng Li, Meimei Li, Xing Tang, Wei Xiao
http://www.scielo.br/pdf/bjps/v54n1/2175-9790-bjps-54-01-e17314.pdf
Development of insulin-loaded nanoparticles. The nanoparticles were synthesized by the combination of two polymers, a polycation, chitosan (low molecular weight. MW, ranging from 50,000 to 190,000 Da), and a polyanion, dextran-sulfate sulfate sodium salt …Author: Tiago Henrique Honorato Gatti, Josimar Oliveira Eloy, Leonardo Miziara Barboza Ferreira, Isabel Cris...
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