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https://www.ijpsonline.com/articles/mucoadhesive-microspheres-of-propranolol-hydrochloride-for-nasal-delivery.html
Bioadhesive microspheres give more residence time to facilitate absorption through nasal mucosa against nasal mucociliary clearance . Gelatin A is an acid hydrolytic product of collagen [ 7 ]. It is bioadhesive and biodegradable polymer that can be used for controlled drug delivery [ 8 ].Author: Pm D, VS Mastiholimath, AP Gadad, SR Iliger
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750719/
The purpose of this research was to prepare spray-dried mucoadhesive microspheres for nasal delivery. Microspheres composed of hydroxypropyl methylcellulose (H), chitosan (CS), carbopol 934P (CP) and various combinations of these mucoadhesive polymers, and maltodextrin (M), colloidal silicon dioxide (A), and propylene glycol (P) as filler and shaper, were prepared by spray-drying technique.Author: Saraporn Harikarnpakdee, Saraporn Harikarnpakdee, Vimolmas Lipipun, Narueporn Sutanthavibul, Garnpim...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751389/
The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of acyclovir. Chitosan, thiolated chitosan, Carbopol 71G and Methocel K15M were used as mucoadhesive polymers. Microsphere ...Author: Sumeet Dhaliwal, Subheet Jain, Hardevinder P. Singh, A. K. Tiwary
https://www.ijpsonline.com/articles/mucoadhesive-chitosan-microspheres-for-noninvasive-and-improved-nasal-delivery-of-insulin.html
Jul 19, 2006 · Therefore, it was aimed to exploit the mucoadhesive property of natural polysaccharide, chitosan and higher permeability, less hostile environment and extended surface area of nasal mucosa to develop mucoadhesive microspheres bearing insulin for the painless delivery of insulin. Insulin has been taken as model peptide.Author: SK Jain, Nitin K Jain, Y Gupta, A Jain, D Jain, M Chaurasia
https://www.ijpsonline.com/articles/mucoadhesive-microspheres-of-propranolol-hydrochloride-for-nasal-delivery.pdf
Mucoadhesive Microspheres of Propranolol Hydrochloride for Nasal Delivery P. M. DANDAGI*, V. S. MASTIHOLIMATH, A. P. GADAD AND S. R. ILIGER Department of Pharmaceutics, K. L. E. S’s College of Pharmacy, J. N. M. C. Campus, Nehru Nagar, Belgaum - 590 010, India. Gelatin A microspheres of propranolol hydrochloride for intranasal systemic ...Author: Pm D, VS Mastiholimath, AP Gadad, SR Iliger
https://www.tandfonline.com/doi/abs/10.3109/02652040802685241
HPMC-based microspheres show adequate mucoadhesion and do not have any destructive effect on nasal mucosa. On the basis of these results, SS microspheres based on HPMC may be considered as a promising nasal delivery system.Author: Snehal A. Jain, Dheeraj S. Chauk, Hitendra S. Mahajan, Avinash R. Tekade, Surendra G. Gattani
https://www.researchgate.net/publication/26494339_Preparation_of_mucoadhesive_microspheres_for_nasal_delivery_by_spray_drying
The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750509/
Finally, histopathological examination did not detect any damage during in vitro permeation studies. In conclusion, the PF 127 gel formulation of sumatriptan, with in situ gelling and mucoadhesive properties with increased permeation rate is promising for prolonging nasal residence time and thereby nasal absorption.Author: Rita J. Majithiya, Pradip K. Ghosh, Manish L. Umrethia, Rayasa S. R. Murthy
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