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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728085/
MRI ocular drug-delivery research is multidisciplinary, requiring familiarity with ocular drug delivery and MRI technology. An objective therefore is to provide both pharmaceutical researchers and MRI scientists with the necessary knowledge to understand and perform MRI studies on ocular drug delivery.Author: S. Kevin Li, Martin J. Lizak, Eun Kee Jeong
https://www.ncbi.nlm.nih.gov/pubmed/18186077
MRI provides a means to non-invasively and continuously monitor ocular drug-delivery systems with a contrast agent or compound labeled with a contrast agent. It is a useful technique in pharmacokinetic studies, evaluation of drug-delivery methods, and drug-delivery device testing.Author: S. Kevin Li, Martin J. Lizak, Eun Kee Jeong
https://onlinelibrary.wiley.com/doi/abs/10.1002/nbm.1230
In the past decade, MRI has been used to examine ocular drug delivery via the subconjunctival route, intravitreal injection, intrascleral injection to the suprachoroidal space, episcleral and intravitreal implants, periocular injections, and ocular iontophoresis.Author: S. Kevin Li, Martin J. Lizak, Eun Kee Jeong
https://www.researchgate.net/publication/5664821_MRI_in_ocular_drug_delivery
MRI provides a means to non-invasively and continuously monitor ocular drug-delivery systems with a contrast agent or compound labeled with a contrast agent. It is a useful technique in...
https://www.deepdyve.com/lp/wiley/mri-in-ocular-drug-delivery-m719c5H4zp
Nov 01, 2008 · MRI in ocular drug delivery The advancement of MRI technology has provided new opportunities in ocular drug‐delivery research. MRI provides a means to non‐invasively and continuously monitor ocular drug‐delivery systems with a contrast agent or compound labeled with a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435115/
Traditional pharmacokinetic studies of eye dissection have yielded important information of these mechanisms, but the traditional pharmacokinetic approaches have limitations. 1 Magnetic resonance imaging (MRI) is a noninvasive method and can be used to study the mechanisms of ocular drug delivery.Author: S. Kevin Li, Jinsong Hao, Hongshan Liu, Jing-huei Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912145/
MRI was also used to directly monitor the subconjunctival and intrascleral infusion methods of drug delivery. Kim et al. (31) also used Gd-DTPA contrast agent to look at distribution and clearance from infusions in the subconjunctival or intrascleral space by dynamic contrast-enhanced MRI.Author: Kelly A. Townsend, Gadi Wollstein, Joel S. Schuman
https://www.liebertpub.com/doi/abs/10.1089/108076801753162807
The delivery of drugs to the retina from solution or from prolonged release forms is considered in terms of pharmacokinetics, interference with vision, and toxicity and safety. It is concluded that visual loss will be the limiting factor in determining the useful life of a drug administered as a microdispersion.Author: David Maurice
https://www.sciencedirect.com/science/article/pii/S2211383516300855
Due to the unique anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to researchers and pharmacologists. Although there are conventional noninvasive and invasive treatments, such as eye drops, injections and implants, the current treatments either suffer from low bioavailability or severe adverse ocular effects.Author: Yuhua Weng, Juan Liu, Shubin Jin, Weisheng Guo, Xingjie Liang, Zhongbo Hu
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0392-8
Sep 19, 2018 · Polymeric micelles are reported to be applicable for both drug delivery against cancer and also for ocular drug delivery as shown in Fig. 3 in which a polymeric micelle is used for reaching the posterior ocular tissues .Author: Jayanta Kumar Patra, Gitishree Das, Leonardo Fernandes Fraceto, Leonardo Fernandes Fraceto, Estefani...
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