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https://www.radiologybusiness.com/topics/care-delivery/gadolinium-free-contrast-agent-mri-radiology
Aug 16, 2019 · A new manganese-based contrast agent could help limit the use of gadolinium-based contrast agents (GBCAs) and make MRI scans more safe, according to new findings published in Investigative Radiology.. Researchers developed the new contrast agent, Mn-PyC3A, to address the various safety concerns surrounding GBCAs, including the retention of residual gadolinium in the body …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003600/
The goals of this study are: (1) to test this Tf-liposome nanocomplex as a targeted MRI probe for systemic delivery of a gadolinium based CA to PC-3M-luc prostate cancer tumor xenografts and (2) to study the relationship of MRI dynamic contrast enhancement patterns with tumor pathology and tumor vasculature after i.v. administration of the ...Author: Alexandru Korotcov, Liang Shan, Huan Meng, Tongxin Wang, Rajagopalan Sridhar, Yuliang Zhao, Xing Jie...
https://pubs.acs.org/doi/10.1021/bc9000454
Molecular imaging of cells and cellular processes can be achieved by tagging intracellular targets such as receptors, enzymes, or mRNA. Seeking to visualize the presence of specific mRNAs by magnetic resonance (MR) imaging, we coupled peptide nucleic acids (PNA) with gadolinium-based MR contrast agents using cell-penetrating peptides for intracellular delivery. Antisense to mRNA of DsRed2 ...Author: Ritu Mishra, Wu Su, Rolf Pohmann, Josef Pfeuffer, Josef Pfeuffer, Martin G. Sauer, Kamil Ugurbil, Jö...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122652/
Jan 01, 2017 · The Effectiveness of Ferritin as a Contrast Agent for Cell Tracking MRI in Mouse Cancer Models. ... as well as a contrast agent for MRI, we used the serotype 5 adenoviral expression system of Ad-hFTH. ... Gene delivery requires a tracking system to monitor targeting efficiency and predict therapeutic efficacy.Author: Chan Wha Lee, Sun Il Choi, Sang Jin Lee, Young Taek Oh, Gunwoo Park, Na Yeon Park, Kyoung Ah Yoon, S...
https://www.researchgate.net/publication/331492853_Ferritin_A_Platform_for_MRI_Contrast_Agents_Delivery
The collected results unequivocally show that the use of ferritin for contrast agent delivery leads to more accurate imaging of cancer cells and a significantly improved targeted therapy ...
https://en.wikipedia.org/wiki/MRI_contrast_agent
Types. Most clinically used MRI contrast agents work by shortening the T1 relaxation time of protons inside tissues via interactions with the nearby contrast agent. Thermally driven motion of the strongly paramagnetic metal ions in the contrast agent generate the oscillating magnetic fields that provide the relaxation mechanisms that enhance the rate of decay of the induced polarization.
https://patents.google.com/patent/WO2013166430A3/en
contrast agent delivery imaging contrast gaseous gaseous imaging Prior art date 2012-05-04 Application number PCT/US2013/039531 Other languages French (fr) Other versions WO2013166430A2 (en Inventor Kiarash EMAMI Stephen J. KADLECEK Rahim R. RIZI Masaru Ishii Hooman HAMEDANI Original Assignee Trustees Of The University Of PennsylvaniaAuthor: Kiarash Emami, Stephen J. Kadlecek, Rahim R. Rizi, Masaru Ishii, Hooman Hamedani
https://onlinelibrary.wiley.com/doi/full/10.1002/aoc.4588
The outcomes indicated that these F@Tyr@CUR NPs are appropriate for delivery of CUR anticancer drug. Also, the MRI training established the effectiveness of Fe 3 O 4 magnetic nanoparticles as contrast agent for the revealing of tumor as evidenced from the phantom images as well as higher T 2 relaxivity.Author: Hamed Nosrati, Jalil Charmi, Somayeh Abedini, Nafis Rashidi, Elahe Attari, Soodabeh Davaran, Hossein...
https://www.howard.edu/medicine/radiology/mil/docs/2010%20JNN_AKorotcov.pdf
A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for MRI Dynamic Contrast Enhancement Study Alexandru Korotcov, 1 Liang Shan, Huan Meng,2 Tongxin Wang,1 Rajagopalan Sridhar,4 Yuliang Zhao,2 Xing-Jie Liang,3 Paul C. Wang1,* 1Department of Radiology, Howard University, Washington DC, 20060, USA 2CAS Key Laboratory for Biomedical Effects of …
https://pubs.acs.org/doi/10.1021/acs.chemrev.8b00363
Oct 16, 2018 · Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are performed annually around the world. The contrast agents, which improve diagnostic accuracy, are almost exclusively small, hydrophilic gadolinium(III) based chelates. In recent years concerns have arisen surrounding the long-term safety of these compounds, and this has spurred research into alternatives. …Author: Jessica Wahsner, Eric M. Gale, Aurora Rodríguez-Rodríguez, Peter Caravan
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