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https://www.sciencedirect.com/science/article/pii/S0168365911009588
1. Introduction. The mechanistic realistic mathematical description of mass transport in controlled drug delivery systems can be highly beneficial , , , , : firstly, it can allow getting deeper insight into the mechanisms, which control drug release from a particular type of dosage forms , , , , , , , , .Thus, the safety of the respective treatment can be improved.Author: Juergen Siepmann, Juergen Siepmann, Florence Siepmann, Florence Siepmann
https://www.researchgate.net/publication/51741916_Modeling_of_diffusion_controlled_drug_delivery
The aim of this article is to give an overview on the current state of the art of modeling drug release from delivery systems, which are predominantly controlled by diffusional mass transport.
https://www.sciencedirect.com/science/article/abs/pii/S0168365911009588
Practical examples illustrate the usefulness of mathematical modeling of diffusion controlled drug delivery. Due to the advances in information technology the importance of in silico optimization of advanced drug delivery systems can be expected to significantly increase in the future.Author: Juergen Siepmann, Juergen Siepmann, Florence Siepmann, Florence Siepmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/
There have been several nicely written reviews on mathematical modeling for bioerodible polymeric delivery systems , dissolution controlled drug delivery systems , microsphere delivery systems and hydrogel networks . In general, diffusion, erosion, and degradation are the most important mechanisms for solute transport from polymeric matrices.Author: Yao Fu, Weiyuan John Kao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518665/
Jan 10, 2013 · For comprehensive coverage of both empirical and mechanistic mathematical models including stochastic methods for PLGA microspheres as well as thorough discussions of mathematical models for diffusion-controlled and swelling-controlled drug delivery systems, the reader is referred to the reviews listed in Table 1 and citations therein.Author: Ashlee N. Ford Versypt, Ashlee N. Ford Versypt, Daniel W. Pack, Daniel W. Pack, Richard D. Braatz, R...
https://www.hansvanlaarhoven.nl/diffusion-based-delivery/
The drug delivery from a diffusion based delivery system can be simulated using the transport of diluted species module in Comsol Multiphysics™. In order to predict how fast the drug diffuses from the active layer to a dissolution vessel or a physiological body, the compartments of the drug delivery system have to be defined in Comsol ...
http://isn.ucsd.edu/courses/beng221/problems/2012/BENG221_Project%20-%20Wei%20Kim%20Kim%20Limsakul.pdf
relaxation of molecular chains, which then allows for drug diffusion out of the rubbery boundary of the polymer. In many cases, a combination of both diffusion and swelling-mediated drug releases occurs [5]. Modeling Assumptions Drug diffusion in a swelling hydrogel Let the drug concentration within the polymer equal c c x y z t , , ,
https://www.researchgate.net/publication/317369587_ROLE_OF_MATHEMATICAL_MODELLING_IN_CONTROLLED_RELEASE_DRUG_DELIVERY
In diffusion controlled sys tems release rate of a drug is ... Mathematical modelling of controlled drug delivery can help prov ide a ... “Modeling of drug release from delivery systems ...
http://www.demonstrations.wolfram.com/DiffusionControlledDrugDelivery/
This Demonstration models a diffusion-controlled drug delivery system to determine the amount of an active pharmaceutical ingredient (API) released from a polymer sphere as a function of time. The elapsed time is limited to 20 hours to correspond to the digestive cycle of humans.
https://link.springer.com/chapter/10.1007%2F978-1-4614-0881-9_6
Sep 27, 2011 · Abstract. This chapter presents an overview on the different types of drug delivery systems that are predominantly governed by diffusion. The systems are classified according to their physical structure (reservoir devices versus monolithic systems), as well as according to the ratio of “initial drug loading and drug solubility.”Author: Juergen Siepmann, Ronald A. Siegel, Florence Siepmann
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