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https://www.nature.com/articles/355279a0
Jan 16, 1992 · Mixed micelles in drug delivery. Large disk-like mixed micelles composed of a drug and biological lipid are thermodynamically stable and represent a novel drug delivery system. Their unique physical properties are reflected in a significantly improved therapeutic index.Author: Danilo D. Lasic
https://www.sciencedirect.com/science/article/pii/B9780128136270000090
Furthermore, the mixed micelles systems may be easily optimized with regard to size and surface charge. Finally, pH-sensitive blocks or surfactant capable of hindering Pgp-mediated drug efflux can be introduced. These nanoparticulate drug delivery systems are also capable of encapsulating a wide range of drugs and can encapsulate two active agents.Author: Jan Sobczyński, Beata Chudzik-Rząd
https://www.sciencedirect.com/topics/materials-science/micelle
The interaction between micelles and lipophilic drugs leads to the formation of mixed micelles (MM), often called swollen micelles. Swollen micelles are fluid systems, but sufficiently stable to be used as delivery systems for stable drugs ( Hammad and Müller, 1998 ).
https://www.researchgate.net/publication/323637815_Mixed_micelles_as_drug_delivery_nanocarriers
ITC data corroborates the fact the binding of PSF is the strongest and thermodynamically most favourable when mixed micelles are formed which enables our system to serve as an excellent drug ...
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00075
Targeted delivery of chemotherapeutics to tumors has the potential to reach a high dose at the tumor while minimizing systemic exposure. Incorporation of antibody within a micellar platform represents a drug delivery system for tumor-targeted delivery of antitumor agents. Such modified immunomicelles can result in an increased accumulation of antitumor agents and enhanced cytotoxicity toward ...
https://www.hindawi.com/journals/jdd/2013/340315/
It allows (1) the delivery of poorly water-soluble drugs; (2) the targeting of drugs to specific parts of the gastrointestinal tract (GI); (3) the transcytosis of drugs across the tight intestinal barrier; and (4) the intracellular and transcellular delivery of large macromolecules [12, 13].Author: Wei Xu, Peixue Ling, Tianmin Zhang
https://www.unmc.edu/pharmacy/faculty/pharmaceutical-sciences/docs/v5.pdf
One of the first reported examples of unimolecular micelles suitable for drug delivery was a threearm star polymer - composed of mucic acid substituted with fatty acids as a lipophilic inner block and PEO as a hydrophilic outer block.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211339/
The drug-free mixed micelles were prepared by rotary evaporation method [23]. In brief, a methanol solution of mPEG-PLA and Solutol HS15 with different molar ratios was evaporated under vacuum at 60°C to form a homogeneous film. The resulting film was dispersed in 10 mL of water at 60°C and then vortexed for 3 min.Author: Xinru Li, Yanhui Zhang, Yating Fan, Yanxia Zhou, Xiaoning Wang, Chao Fan, Yan Liu, Qiang Zhang
https://www.ncbi.nlm.nih.gov/pubmed/20700632
Mixed polymer micelles suppress cancer cell growth effectively in a drug concentration, mixing method and schedule-dependent way. CONCLUSION: Combination chemotherapy using polymeric micelles seems to minimize a schedule-dependent change in combination drug efficacy in comparison to drug combination using DMSO formulations.Author: Younsoo Bae, Adam W. G. Alani, Nicole C. Rockich, T. S. Z. Chung Lai, Glen S. Kwon
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