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https://www.sciencedirect.com/science/article/pii/S0169409X97000690
The formulation of all kinds of microspheres as nasal drug delivery systems for peptides and proteins ought to take into account studies of the time for complete swelling of the spheres and the release rate of the incorporated drug under conditions resembling the situation in the nasal cavity.Author: Lena Pereswetoff-Morath
https://www.frontiersin.org/articles/10.3389/fphar.2020.00230/full
The purpose of this work was to prepare APS/CTS microspheres intended for nasal drug delivery by the spray-drying method. The characteristics of APS/CTS microspheres were evaluated by a scanning electron microscope, Fourier transform infrared spectroscopy, differential scanning calorimetry, and in vitro drug release.Author: Saisai Wang, Yuqing Sun, Jingjing Zhang, Xiaoming Cui, Zhilu Xu, Dejun Ding, Limin Zhao, Wentong Li,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750719/
The purpose of this research was to prepare spray-dried mucoadhesive microspheres for nasal delivery. Microspheres composed of hydroxypropyl methylcellulose (H), chitosan (CS), carbopol 934P (CP) and various combinations of these mucoadhesive polymers, and maltodextrin (M), colloidal silicon dioxide (A), and propylene glycol (P) as filler and shaper, were prepared by spray-drying technique.Author: Saraporn Harikarnpakdee, Saraporn Harikarnpakdee, Vimolmas Lipipun, Narueporn Sutanthavibul, Garnpim...
https://www.ncbi.nlm.nih.gov/pubmed/27834150
Sep 06, 2017 · Thus, in order to extend the residence time of Rg3 in the nasal cavity, a new drug delivery system is needed. METHODS: Chitosan microspheres loaded with Rg3 were prepared using a multi-step emulsification method and were characterized in vitro and in vivo. RESULTS: The microspheres had a spherical shape with a mean diameter of 44.9±12.6 08m.Author: Wei Zhang, Xiaoyu Wang, Min Zhang, Min Xu, Wenyan Tang, Yi Zhang, Lei Lu, Jing Gao, Shen Gao
https://www.sciencedirect.com/science/article/pii/037851739090232S
This dehydration might induce reversible shrinking of the epithelial cells and widening of the tight junctions, thereby en- hancing the transport of hydrophilic components such as insulin. 192 References Bjk, E. and Edman, P., Degradable starch microspheres as a nasal delivery system for insulin.Author: Erik Björk, Peter Edman
https://www.ijpsonline.com/articles/mucoadhesive-microspheres-of-propranolol-hydrochloride-for-nasal-delivery.html
Bioadhesive microspheres give more residence time to facilitate absorption through nasal mucosa against nasal mucociliary clearance . Gelatin A is an acid hydrolytic product of collagen [ 7 ]. It is bioadhesive and biodegradable polymer that can be used for controlled drug delivery [ 8 ].Author: Pm D, VS Mastiholimath, AP Gadad, SR Iliger
https://www.tandfonline.com/doi/abs/10.3109/02652040802685241
The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time. For the treatment of migraine, hydroxypropyl methylcellulose (HPMC) K4M and K15M based microspheres containing sumatriptan succinate (SS) were prepared by spray-drying technique.Author: Snehal A. Jain, Dheeraj S. Chauk, Hitendra S. Mahajan, Avinash R. Tekade, Surendra G. Gattani
https://www.researchgate.net/publication/327555752_Rizatriptan_benzoate_loaded_natural_polysaccharide_based_microspheres_for_nasal_drug_delivery_system
microspheres for the nasal drug delivery system. Method s: The polysacch aride was extra cted from the seed of Trigonella foenum-graecum and microspheres were p repared by emulsif ication,
http://ijpsr.com/bft-article/formulation-and-evaluation-of-levocetirizine-loaded-mucoadhesive-microspheres-for-nasal-delivery/?view=fulltext
ABSTRACT: The purpose of research work was to develop and optimize mucoadhesive microspheres of levocetirizine for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy and at the same time increase the Local absorption of drug and reducing systemic side effects and also to develop unique delivery system for patients suffering from allergy and rhinitis.
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