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https://www.researchgate.net/publication/279416395_Microparticles_as_Vaccine_Adjuvants_and_Delivery_Systems
Vaccine-delivery systems generally are particulate (e.g., emulsions, microparticles, iscoms, and liposomes) and function mainly to target associated antigens into antigen-resenting cells.
https://www.sciencedirect.com/science/article/pii/B9780120884032500095
Therefore, a range of alternative particulate carriers have been widely used as vaccine delivery systems. Immunopotentiators may also be included in the delivery systems to enhance the response by focusing its effects on the APC which take up the particulate carriers.Author: Derek T. O'Hagan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465129/
VACCINE DELIVERY SYSTEMS. Delivery of antigens from oil-based adjuvants such as Freunds[] adjuvant lead to a reduction in the number of doses of vaccine to be administered but due to toxicity concerns like inductions of granulomas at the injection site, such adjuvants are not widely used.FDA approved adjuvants for human uses are aluminium hydroxide and aluminium phosphate in the form of …
https://onlinelibrary.wiley.com/doi/abs/10.1002/3527601449.ch8
Particulate Vaccine Delivery Systems Lipid‐based Particles as Adjuvants. The Adjuvant Effect of Synthetic Particles. Uptake of Microparticles into APC. Microparticles as Adjuvants for Antibody Induction. The Induction of Cell‐mediated Immunity with Microparticles. Microparticles as …Author: Derek T O’Hagan, Manmohan Singh
https://www.researchgate.net/publication/10628480_O'Hagan_D_T_Singh_M_Microparticles_as_vaccine_adjuvants_and_delivery_systems_Expert_Rev_Vaccines_2_269-283
O'Hagan, D. T. & Singh, M. Microparticles as vaccine adjuvants and delivery systems. Expert Rev. Vaccines 2, 269-283 Article · Literature Review in Expert Review of Vaccines 2(2):269-83 · May ...
https://www.sciencedirect.com/science/article/pii/B9780323399814000142
In recent years, numerous efforts have been made to develop microparticulate-engineered delivery systems and novel vaccine adjuvants against bacterial and viral infections, cancers, intracellular pathogens, HIV, etc. Table 14.2 summarizes some studies …Author: N. Mody, R. Sharma, S. Dubey, S.P. Vyas
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963573/
Nano-microparticles as immune adjuvants. Examples of materials that have been used to prepare nano-microparticles as vaccine-delivery systems include polymers [], copolymers [] and lipids [44–46].The choice of material in particle preparation is guided by many factors, such as biocompatibility, degradation rate, hydrophilicity or lipophilicity, and polarity.Author: Moses O Oyewumi, Amit Kumar, Zhengrong Cui
https://onlinelibrary.wiley.com/doi/book/10.1002/9780470134931
Nov 02, 2006 · MANMOHAN SINGH, M.Pharm., PhD, has worked in the area of vaccine adjuvants and delivery systems for seventeen years and has authored over eighty-five manuscripts and review articles.Dr. Singh is on the editorial board of five international journals and has contributed several book chapters. He is a Director of Vaccine Research within Novartis Vaccines.
https://www.pnas.org/content/97/2/811
Jan 18, 2000 · An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection. The microparticles released intact and functional DNA over 2 weeks in vitro . In addition, the microparticles induced higher levels of marker gene expression in vivo . After i.m. immunization, the ...Author: Manmohan Singh, Maylene Briones, Gary Ott, Derek O'Hagan
https://www.semanticscholar.org/paper/Biodegradable-Nanoparticles-as-Vaccine-Adjuvants-of-Akagi-Baba/1e07d1ef13a3e546b12369d9c021b80a673fe7a0
@inproceedings{Akagi2011BiodegradableNA, title={Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine}, author={Takami Akagi and Masanori Baba and Mitsuru Akashi}, year={2011} } Polymeric nano- and microparticles have ...
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