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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794664/
Oct 14, 2019 · Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for ...
https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/microneedle/
3M Microneedle Drug Delivery Systems, which include Hollow Microneedle and Solid Microneedle technology, offer patient-friendly delivery solutions for vaccines or difficult-to-deliver biologics for particularly needle-phobic patients. By potentially reducing anxiety, microneedle delivery may improve patient compliance in some patient groups.
https://www.medicaldesignandoutsourcing.com/microneedle-technology-transdermal-drug-delivery/
Jun 23, 2016 · A subset of transdermal drug delivery, microneedle technology using liquid silicone rubber (LSR), provides stronger, smaller polymers that are more stable and can last longer through multiple uses. This is helping to drive the growth of the transdermal drug delivery market. We look now at manufacturing and engineering progression as part of this growth.
https://www.sciencedirect.com/science/article/pii/S2211383518312437
The emerging devices, microneedle patches, are often regarded as potential candidates for hypodermic injection, which is painless, safe, and simple for patients to self-administer. Transdermal drug delivery for disease treatment is still the hot spot of application for microneedles. 3.2.1. CancerAuthor: Jian Yang, Xinli Liu, Yunzhi Fu, Yujun Song
https://patents.google.com/patent/US6611707B1/en
Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir ...Author: Mark R. Prausnitz, Mark G. Allen, Inder-Jeet Gujral
https://www.sciencedirect.com/science/article/abs/pii/S0169409X12001251
Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug ...Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://drug-dev.com/recent-developments-in-microneedle-technology-for-transdermal-drug-delivery-vaccination/
Mikolaj Milewski and Amitava Mitra highlight some of the recent advances in the field of microneedle-mediated transdermal drug delivery and vaccination, including summaries of preclinical pharmacokinetic data and a brief overview of clinical studies, encompassing the time period from 2010 to present day.
https://www.nature.com/articles/s41378-018-0039-9
Dec 17, 2018 · A technique for turning polymer films into a fracture-resistant, glassy form of carbon could hold promise for drug delivery. Microneedles are devices designed to inject or infuse medications into ...Author: Richa Mishra, Bidhan Pramanick, Tapas Kumar Maiti, Tarun Kanti Bhattacharyya
https://www.ondrugdelivery.com/transdermal-delivery-device-design/
As the drug is delivered from the DIA patch the drug concentration will eventually begin to fall. The delivery rate therefore falls off over time and this fact needs to be considered in the clinical evaluation phase of development. A significant problem with most of the main forms of transdermal patch is the intermingling of the drug with ...
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