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https://www.sciencedirect.com/science/article/pii/S0927796X16300213
Transdermal drug delivery offers a number of advantages for the patient, due not only its non-invasive and convenient nature, but also factors such as avoidance of first pass metabolism and prevention of gastrointestinal degradation.Author: Eneko Larrañeta, Rebecca E.M. Lutton, A. David Woolfson, Ryan F. Donnelly
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627464/
Dec 05, 2012 · 1. Introduction. Microneedle arrays (MN) are minimally-invasive devices that painlessly by-pass the skin's stratum corneum, which is the principal barrier to topically-applied drugs. 1 MN (50–900 μm in height, up to 2000 MN cm −2) have been extensively investigated in recent years as a means to enhance transdermal drug and vaccine delivery. 2 – 10 No MN array-based drug delivery …Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Rita Majithiya, Cia...
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
2.1.1. First studies of transdermal delivery. Henry et al. conducted the first study to determine if microneedles could be used to increase transdermal drug delivery. An array of solid microneedles was embedded in cadaver skin, which caused skin permeability to a small model compound, calcein, to increase by three orders of magnitude.Author: Mark R Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039970/
Thus, microneedle‐based transdermal drug delivery approaches have been investigated by changing different kinds of materials and configurations. 14, 15, 16, ... Toward Self‐Powered Wearable Adhesive Skin Patch with Bendable Microneedle Array for Transdermal Drug Delivery. Adv.Author: Hao Wang, Giorgia Pastorin, Giorgia Pastorin, Chengkuo Lee
https://link.springer.com/article/10.1007%2Fs10404-006-0083-x
Mar 04, 2006 · Many of the compounds in drugs cannot be effectively delivered using current drug delivery techniques (e.g., pills and injections). Transdermal delivery is an attractive alternative, but it is limited by the extremely low permeability of the skin. As the primary barrier to transport is located in the upper tissue, Micro-Electro-Mechanical-System (MEMS) technology provides novel means, such as ...Author: Bin Ma, Sheng Liu, Sheng Liu, Zhiyin Gan, Guojun Liu, Xinxia Cai, Honghai Zhang, Zhigang Yang
https://www.researchgate.net/publication/225325139_Silicon_Microneedle_array_with_Biodegradable_Tips_for_Transdermal_drug_delivery
This paper presents the fabrication process, characterization results and basic functionality of silicon microneedle array with biodegradable tips for transdermal drug delivery.
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.201200864
and transdermal drug delivery is now controlled by the crosslink density of the hydrogel system rather than the stratum corneum, while electrically modulated delivery is also a unique feature. Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery Unique microneedle arrays prepared from crosslinked polymers, which con-Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska, Rita Majithiya, Cia...
https://www.researchgate.net/publication/252739896_Microneedles_array_with_biodegradable_tips_for_transdermal_drug_delivery
The paper presented an enhancement solution for transdermal drug delivery using microneedles array with biodegradable tips. The microneedles array was fabricated by using deep reactive ion etching ...
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Microneedle application is an emerging technique for transdermal drug delivery and this is reflected by the large number of patent applications filed. 125-133 The majority of these patent applications are focused around design of, and delivery through, hollow microneedles since a higher amount of drug can be delivered from such microneedles as ...Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
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