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https://ieeexplore.ieee.org/document/659807/
Micromachined needles for the transdermal delivery of drugs Abstract: Although modern biotechnology has produced extremely sophisticated and potent drugs, many of these compounds cannot be effectively delivered using current drug delivery techniques (e.g., pills and injections).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · Transdermal MNs create micron sized pores in the skin to enhance delivery of the drug across the skin [11,13]. MN are ideal for patient adherence as they do not stimulate nerves that are associated with pain.Author: Kevin B. Ita
https://www.pnas.org/content/pnas/100/24/13755.full.pdf
transdermal drug delivery skin microelectromechanical systems solid microneedle alignment step, microneedles were etched around the holes ashollow needle injection H ypodermic needles have provided the gold standard for drug delivery for over a century, but advances in biotech-Author: Devin V. McAllister, Ping M. Wang, Shawn P. Davis, Jung-Hwan Park, Paul J. Canatella, Mark G. Allen,...
http://www-eng.lbl.gov/~dw/if/ideas/mems/mems_2002_papers/036.pdf
Nowadays, typical routes for drug delivery are either through hypodermic needles or by oral administration, while diagnostic sampling in most cases requires extraction of blood through a hypodermic syringe needle, followed by analysis of blood components in a …
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https://www.sciencedirect.com/science/article/pii/S0022354915506242
Henry, D.V. McAllister, M.G. Allen, M.R. Prausnitz, Micromachined needles for the transdermal delivery of drugs Micro Electro Mechanical Systems. (1998) Institute of Electrical and Electronics Engineers Piscataway, NJ 494-498 18.Author: Sebastien Henry, Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://ieeexplore.ieee.org/document/805145/
Micromachined needle arrays for drug delivery or fluid extraction Abstract: Micromachined needle arrays have been designed, fabricated, and characterized. The design includes arrays of 25 needles with fluid coupling channels and dual structural supports.
https://www.europepmc.org/articles/PMC5302820/
Feb 10, 2017 · Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery. Find the latest peer-reviewed research articles and preprints on Coronavirus here. Feedback Complete survey. Sign in or create an account. https ...Author: Jiyu Li, Bin Liu, Yingying Zhou, Zhipeng Chen, Lelun Jiang, Wei Yuan, Liang Liang
https://www.sciencedirect.com/science/article/pii/S1549963405000547
A nanometer coating on the microneedles ensured the biocompatibility that is important in the application of transdermal drug delivery. Model drugs selected to investigate skin permeation in vitro were calcein, a small molecule (molecular weight, 623 d) that has little skin penetration, and bovine serum albumin (BSA) (molecular weight, 66,000 d), a hydrophilic biological macromolecule.Author: Yu Xie, Bai Xu, Yunhua Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Today, there are 19 transdermal delivery systems for such drugs as estradiol, fentanyl, lidocaine and testosterone; combination patches containing more than one drug for contraception and hormone replacement; and iontophoretic and ultrasonic delivery systems for analgesia ( Table 1, Fig. 1 ).Author: Mark R Prausnitz, Robert Langer
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