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https://www.annualreviews.org/doi/10.1146/annurev.bioeng.2.1.289
Abstract By incorporating techniques adapted from the microelectronics industry, the field of microfabrication has allowed the creation of microneedles, which have the potential to improve existing biological-laboratory and medical devices and to enable novel devices for gene and drug delivery. Dense arrays of microneedles have been used to deliver DNA into cells.Author: Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://www.researchgate.net/publication/313724980_Microfabricated_microneedles_for_gene_and_drug_delivery
In most cases, in-plane microneedles are fabricated with conventional silicon MEMS techniques and can be used for precise drug delivery to a target region or tissue of the body [1], whereas out-of ...
https://www.sciencedirect.com/science/article/pii/S0022354915506242
This paper describes the first published study on the use of microfabricated microneedles to enhance drug delivery across skin. References and Notes 1. R. Langer, New methods of drug delivery Science 249: (1990) 1527-1533 2. R.G. Crystal, Transfer of genes to humans: early lessons and obstacles to success Science 270: (1995) 404-410 3. Z.Author: Sebastien Henry, Devin V. McAllister, Mark G. Allen, Mark R. Prausnitz
https://onlinelibrary.wiley.com/doi/pdf/10.1021/js980042%2B
Jun 12, 2000 · Limited tests on human subjects indicated that microneedles were reported as painless. This paper describes the first published study on the use of microfabricated microneedles to enhance drug delivery across skin.
http://mems.seas.upenn.edu/publications/2000/Microfabricated%20Microneedles%20for%20Gene%20and%20Drug%20Delivery.pdf
for gene and drug delivery. Microfabrication [i.e. micromachining or microelec-tromechanical systems (MEMS)] uses tools developed by the microelectronics industry to make integrated circuits (ICs) and consists of a broad range of tech-nologies anchored in the core technology of microlithographic pattern transfer (4–6).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906704/
Hollow microneedles for suprachoroidal drug delivery to the posterior segment of the eye. Controlled Release Society. 2009 Jul 18–22; Pearton M, Allender C, Brain K, Anstey A, Gateley C, Wilke N, Anthony M, Birchall J. Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations.Author: Ryan F. Donnelly, Thakur Raghu Raj Singh, A. David Woolfson
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.2004.05921.x
Grace Cole, Nicholas J. Dunne and Helen O. McCarthy, Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers, Microneedles for Drug and Vaccine Delivery and Patient Monitoring, (129-175), (2018).Author: F. Chabri, K. Bouris, T. Jones, David Anthony Barrow, Anthony Hann, C. Allender, K. Brain, J. Bircha...
https://www.europepmc.org/articles/PMC4529475/
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https://www.researchgate.net/publication/11652213_McAllister_DV_Allen_MG_Prausnitz_MRMicrofabricated_microneedles_for_gene_and_drug_delivery_Annu_Rev_Biomed_Eng_2289-313
Finally, microhypodermic needles and microneedles for transdermal drug delivery have been developed to reduce needle insertion pain and tissue trauma and to provide controlled delivery …
https://www.sciencedirect.com/science/article/pii/S0169409X03002394
2. Transdermal drug delivery using microneedles. The overarching motivation for microneedles is that they can provide a minimally invasive means to transport molecules into the skin. Guided by this goal, a number of specific strategies have been employed to use microneedles for transdermal delivery.Author: Mark R Prausnitz
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