Microemulsions For Oral Delivery Of Insulin

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Microemulsions for oral delivery of insulin: Design ...

    https://www.sciencedirect.com/science/article/pii/S0939641110001852
    Insulin loaded microemulsions were developed adopting a low shear reverse micellar approach using didoceyldimethylammonium bromide (DMAB) as the surfactant, propylene glycol (PG) as the co-surfactant, triacetin (TA) as the oil phase and insulin solution as the aqueous phase.Author: G. Sharma, K. Wilson, C.F. van der Walle, N. Sattar, J.R. Petrie, M.N.V. Ravi Kumar

Microemulsion-based approach for oral delivery of insulin ...

    https://www.cell.com/heliyon/pdf/S2405-8440(20)30495-3.pdf
    Microemulsion-based approach for oral delivery of insulin: formulation design and characterization Mumuni A. Momoh a,* , Kenechukwu C. Franklin a , Chinazom P. Agbo a , Calister E. Ugwu b ,

Microemulsions for oral delivery of insulin: design ...

    https://www.sigmaaldrich.com/catalog/papers/20655382
    The conformational stability of the entrapped insulin within microemulsions was confirmed by fluorescence spectroscopy and circular dichroism. The microemulsions displayed a 10-fold enhancement in bioavailability compared with plain insulin solution administered per oral in healthy rats.

Microemulsion-based approach for oral delivery of insulin ...

    https://www.cell.com/heliyon/fulltext/S2405-8440(20)30495-3
    Biotechnology; Materials application; Materials characterization; Pharmaceutical chemistry; Biological sciences; Pharmacology; Mucin, Tween® 80, Microemulsions, Oral ...

Microemulsions for oral delivery of insulin : design ...

    https://strathprints.strath.ac.uk/31955/
    Insulin loaded microemulsions were developed adopting a low shear reverse micellar approach using didoceyldimethylammonium bromide (DMAB) as the surfactant, propylene glycol (PG) as the co-surfactant, triacetin (TA) as the oil phase and insulin solution as the aqueous phase.Author: G. Sharma, K. Wilson, C.F. van der Walle, N. Sattar, J.R. Petrie, M.N.V. Ravi Kumar

Challenges for the oral delivery of macromolecules ...

    https://www.nature.com/articles/nrd1067
    Apr 01, 2003 · The rapid integration of new technologies by the pharmaceutical industry has resulted in numerous breakthroughs in the discovery, development and manufacturing of pharmaceutical products.Author: Michael Goldberg, Isabel Gomez-Orellana

Microemulsion - an overview ScienceDirect Topics

    https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/microemulsion
    Microemulsions for insulin delivery consisted of a mixture of medium-chain mono-, di-, and tri-glycerides as the oil component and polysorbate 80, sorbitan mono-oleate, oleic acid, labrasol, glyceryl oleate, propylene carbonate, and transcutol P as surfactants/cosurfactants [174–178].

Oral Delivery of Insulin: Novel Approaches IntechOpen

    https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/oral-delivery-of-insulin-novel-approaches
    The improved oral delivery of insulin from a microemulsion system was also demonstrated by others . A stable self-emulsifying formulation for the oral delivery of insulin was developed by Ma et al. . It is composed of two non-ionic surfactants (polyethylene glycol-8-glycol octanoate/decanoate and polyglycerol-3 oleate).Author: Amani M. Elsayed

Ionic liquids for oral insulin delivery PNAS

    https://www.pnas.org/content/115/28/7296
    Jul 10, 2018 · Insulin is not available in the clinic as an oral pill and is almost exclusively administered as an s.c. injection. However, despite its effectiveness in the management of hyperglycemia and mitigating risks of neuropathy, nephropathy, and retinopathy, injectable insulin has lower patient compliance due to pain,...Author: Amrita Banerjee, Kelly Ibsen, Kelly Ibsen, Tyler Brown, Renwei Chen, Christian Agatemor, Samir Mitra...

Evaluation of an oral insulin formulation in normal and ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271511/
    The polar system of oral insulin produced dose-dependent reduction in blood glucose in normal and diabetic rats. This formulation significantly reduced blood glucose from 100 mg/dl (before treatment) to 33.73 mg/dl 4 h after treatment in normal rats (P<0.05). This change was dependent to …

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