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https://patents.google.com/patent/US5797898A/en
673 rows · Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or other molecules to be delivered and the surrounding fluids is used as the substrate.Author: John T. Santini, Michael J. Cima, Robert S. Langer
https://patents.google.com/patent/US7070590B1/en
Devices are provided for the controlled release of drug or other molecules. The devices include (1) a substrate, which optionally includes two or more substrate portions bonded together, (2) at least two reservoirs in the substrate, (3) a release system disposed in the reservoirs that includes the molecules for release and optionally a matrix material, and (4) active or passive means for ...Author: John T. Santini, Michael J. Cima, Robert S. Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914739/
Jun 07, 2016 · In 1998, the US Patent “Microchip Drug Delivery Devices” was awarded to Santini Jr. et al., which first outlined the parameters of a multireservoir microchip system with an active release system . In 1999, Santini Jr. et al. debuted the first electrochemically activated drug delivery microchip .Author: Adam E. M. Eltorai, Henry Fox, Emily McGurrin, Stephanie Guang
http://europepmc.org/patents/PAT/EP0914092
MICROCHIP DRUG DELIVERY DEVICES (PAT - EP0914092) CIMA Michael J. ... Patent: Publ. of Application without search report - European Patent Office. ... Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. A release system, which includes the molecules to be delivered, is inserted into the reservoirs ...
http://www.freepatentsonline.com/5797898.html
Aug 25, 1998 · Microchip drug delivery devices . United States Patent 5797898 ... Microchip devices have been provided which can accurately deliver drugs and other molecules at defined rates and times according to the needs of the patient or other experimental system. As used herein, a "microchip" is a miniaturized device fabricated using methods commonly ...
http://europepmc.org/patents/PAT/US5797898
Microchip drug delivery devices (PAT - US5797898) ' ' SANTINI JR JOHN T, ' ' CIMA ... Patent: United STATES Patent - United States. Application: ... Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. The molecules to be delivered are inserted into the reservoirs by injection or spin coating ...
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/microchip
Similarly, US patent no. US 5797898 described the various design of microchip drug delivery design for potential application in local brain delivery. The patent has described both active and passive devices. The patent disclosed that the implantable microchip device can be used to locally deliver the chemotherapeutic agents which can be used in ...
https://www.sciencedirect.com/science/article/pii/S1773224717302186
The first patent on microchip drug delivery devices was awarded to a group of scientists from Massachusetts Institute of Technology in 1998 . Since then many patents have been awarded based on refined fabrication methods [13] , microchip applications to ophthalmology [12] and wireless data and power transfer [16] .Author: Rajesh Vadlapatla, Eva Y. Wong, Sanjaykumar G. Gayakwad
http://www.freepatentsonline.com/7582080.html
Sep 01, 2009 · The devices described herein have a wide variety of both medical and non-medical uses. For example, other medical applications for the microchip devices include drug delivery and sensing at sites such as the wall (interior or exterior side) of a blood …
http://scholar.google.com/citations?user=xyXF27EAAAAJ&hl=en
Multi-pulse drug delivery from a resorbable polymeric microchip device ACR Grayson, IS Choi, BM Tyler, PP Wang, H Brem, MJ Cima, R Langer Nature materials 2 (11), 767-772 , 2003
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