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https://www.sciencedirect.com/science/article/pii/S0169409X10000402
Immunoprotection of transplanted cells and tissues by size-based semipermeable membranes allows the in situ delivery of secreted proteins to treat different pathological conditions such as CNS diseases, diabetes mellitus, hepatic diseases, amyotrophic lateral sclerosis, hemophilia, hypothyroidism and cardiovascular diseases among others , , , , . Such cell-based devices are thought to hold great promise in applications requiring site-specific and sustainable drug delivery of cell-synthesized ...Author: Rosa Ma Hernández, Rosa Ma Hernández, Gorka Orive, Gorka Orive, Ainhoa Murua, Ainhoa Murua, José Lui...
https://www.sciencedirect.com/science/article/abs/pii/S0169409X10000402
Cell microencapsulation is a promising tool to overcome these drawbacks. It consists of surrounding cells with a semipermeable polymeric membrane. The latter permits the entry of nutrients and the exit of therapeutic protein products, obtaining in this way a sustained delivery of the desirable molecule.Author: Rosa Ma Hernández, Rosa Ma Hernández, Gorka Orive, Gorka Orive, Ainhoa Murua, Ainhoa Murua, José Lui...
https://www.ncbi.nlm.nih.gov/pubmed/20153388
Jun 15, 2010 · Microcapsules and microcarriers for in situ cell delivery. Hernández RM(1), Orive G, Murua A, Pedraz JL. Author information: (1)University of the Basque Country, Vitoria-Gasteiz, Spain. In recent years, the use of transplanted living cells pumping out active factors directly at the site has proven to be an emergent technology.Author: Rosa Ma Hernández, Rosa Ma Hernández, Gorka Orive, Gorka Orive, Ainhoa Murua, Ainhoa Murua, José Lui...
https://www.researchgate.net/publication/41427792_Microcapsules_and_microcarriers_for_in_situ_cell_delivery
Apart from the capsule size, the uniformity of the microcapsules is another factor that affects diffusive transport in implantation proce- dures. 40 The results for the microcapsules formed by an 18 G (OD) needle are shown in Figure 5a, with similar trends being seen for the 22 G (OD)...
https://www.academia.edu/13298027/Microcapsules_and_microcarriers_for_in_situ_cell_delivery
Microcapsules and microcarriers as a tool for immune system may lead to a variety of undesired complications in regenerative medicine patients (e.g., opportunistic infections, failure of tumor surveillance) [28–30]. By surrounding a transplant with a membrane barrier,...
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201901397
In this study, the highly open porous microspheres (HOPMs) are fabricated using a microfluidic technique for harboring proliferating skeletal myoblasts and evaluating their feasibility toward cell delivery application in situ. These biocompatible HOPMs with particle sizes of 280–370 µm possess open pores of 10–80 µm and interconnected paths.Author: Ranjith Kumar Kankala, Jia Zhao, Chen‐Guang Liu, Xiao‐Jie Song, Da‐Yun Yang, Kai Zhu, Shi‐Bin Wang, ...
https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201970132
These modular cell‐laden microcarriers potentially allow for in situ tissue construction after minimally invasive delivery, providing a convenient means for regeneration medicine. The caption was modified on 25 June, 2019 after initial online publication.Author: Ranjith Kumar Kankala, Jia Zhao, Chen‐Guang Liu, Xiao‐Jie Song, Da‐Yun Yang, Kai Zhu, Shi‐Bin Wang, ...
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