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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084724/
Ultrasound mediated drug delivery using microbubbles is a safe and noninvasive approach for spatially localized drug administration. This approach can create temporary and reversible openings on cellular membranes and vessel walls (a process called “sonoporation”), allowing for enhanced transport of therapeutic agents across these natural barriers.Author: Tzu-Yin Wang, Katheryne E. Wilson, Steven Machtaler, Jurgen K. Willmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC538251/
Nov 16, 2004 · Mechanisms for Target Drug Delivery Using Microbubbles. Two possible strategies for delivering drugs and genes with microbubbles are emerging. The first consists on the ultrasound-mediated microbubble destruction, which is based on the cavitation of microbubbles induced by ultrasound application, and the second is the direct delivery of substances bound to microbubbles in …Author: Jeane M Tsutsui, Feng Xie, Richard Thomas Porter
https://www.sciencedirect.com/science/article/pii/S0168365914007342
1. Introduction. While ultrasound is a well-established diagnostic imaging technique, its great potential in enhancing drug delivery was only acknowledged in the late 1990s .Since then, the ultrasound mediated uptake of small drugs , proteins , as well as larger nanoparticles such as gene complexes or drug loaded liposomes has been reported. In these studies, ultrasound is often used in ...Author: Ine De Cock, Elisa Zagato, Kevin Braeckmans, Ying Luan, Nico de Jong, Stefaan C. De Smedt, Ine Lenta...
https://mbi-ctac.sites.medinfo.ufl.edu/files/2017/02/Ultrasound-microbubble-fundamentals-and-gene-delivery-Ferrara-et-al-2007.pdf
ties for drug delivery. Creation of a clinically optimized microbubble-based drug or gene delivery vehicle is challenging because there exists a vast parameter space of po-tential shell materials, targeting ligands, cargos, and ultrasound parameters. Herein, engineering analyses of both the microbubble shell and gas core are reviewed. As-
https://jtultrasound.biomedcentral.com/articles/10.1186/2050-5736-1-10
Jul 01, 2013 · Ultrasound-targeted microbubble destruction (UTMD) is a promising technique for non-invasive, targeted drug delivery, and its applications in chemotherapeutic drug delivery to solid tumors have attracted growing interest. Ultrasound, which has been conventionally used for diagnostic imaging, has evolved as a promising tool for therapeutic applications mainly because of its ability to be ...Author: Hong Chen, Joo Ha Hwang
https://www.sciencedirect.com/science/article/pii/S0929644114001635
Microbubble-enhanced Focused Ultrasound-induced Blood–brain Barrier Opening for Local and Transient Drug Delivery in Central Nervous System DiseaseAuthor: Ching-Hsiang Fan, Chih-Kuang Yeh
https://www.researchgate.net/publication/317589821_Ultrasound-guided_drug_delivery_in_cancer
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues ...
https://www.nature.com/articles/s41598-018-35677-w
Dec 07, 2018 · Focused ultrasound (FUS) with the presence of microbubbles induces blood brain barrier (BBB) opening in targeted areas and facilitates drug delivery. …Author: Hong-Chieh Tsai, Hong-Chieh Tsai, Chih-Hung Tsai, Wen-Shiang Chen, Claude Inserra, Kuo-Chen Wei, Hao...
https://www.scintica.com/new-journal-article-ultrasound-induced-microbubble-cavitation-via-a-transcanal-or-transcranial-approach-facilitates-inner-ear-drug-delivery/
In a recent paper published in JCI Insight, researchers have demonstrated for the first time the feasibility of applying Ultrasound-induced Microbubble Cavitation via the external auditory canal as a technique to increase the efficiency of drug delivery to the inner ear.
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