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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430809/
This review covers reservoir-based drug delivery systems that incorporate microtechnology, with an emphasis on oral, dermal, and implantable systems. Key features of each technology are highlighted such as working principles, fabrication methods, dimensional constraints, and performance criteria.Author: Cynthia L. Stevenson, John T. Santini, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576846/
Micro- & nano-technology enabled implantable drug-delivery systems. Micro- and nano-technology has enhanced the design features of implantable systems. The size of individual components as well as whole systems has been miniaturized to a minimally invasive implantable form factor.Author: Ellis Meng, Tuan Hoang
https://journals.sagepub.com/doi/full/10.1177/2211068211428189
Jan 27, 2012 · The reservoir-based system is one of the most common controlled drug delivery systems to date. In these systems, a drug core is surrounded by a polymer film, and the drug release rate is controlled by the properties of the polymer (e.g., polymer composition and molecular weight), the thickness of the coating, and the physicochemical properties of the enclosed drug, such as solubility, …Author: Wan-Wan Yang, Erik Pierstorff
http://biomems.usc.edu/publications/2012/2012-TDE-micronano-drug-delivery.pdf
drug-delivery systems Implantable drug-delivery systems provide new means for achieving therapeutic drug concentrations over entire treatment durations in order to optimize drug action. This article focuses on new drug administration modalities achieved using implantable drug-delivery systems that are enabled by micro- and nano-fabrication ...Location: microfluidics
http://iopscience.iop.org/article/10.1088/1758-5082/5/2/025011/pdf
store drug molecules in each reservoir in the range of ‘a few to tens of micrograms per each reservoir’ [23, 28]. In this study, we investigated the possibility of ‘wet’ μCP to transfer and load drug molecules in the quantity of a few micrograms, particularly suited for micro-reservoir-type drug delivery systems (DDS) (figure 1). As shown
https://www.sciencedirect.com/science/article/pii/S0169409X17301941
Similarly, Spieth et al. proposed another micro-reservoir-based implantable micropump for passive drug delivery .Each micro-reservoir was preloaded with 0.25 μL of drug solutions before implantation, and the drug was displaced from the reservoirs due to local and irreversible thermal expansion by short heating pulses applied to a polydimethylsiloxane (PDMS) layer containing Expancel microspheres.Author: Sharma T. Sanjay, Wan Zhou, Maowei Dou, Maowei Dou, Hamed Tavakoli, Lei Ma, Feng Xu, XiuJun Li
https://path.azureedge.net/media/documents/DT_update_micro_patches_drug.pdf
transferring the drug from a solid drug reservoir embedded within the patch to deliver it to the patient. As an easy-to-use and discreet delivery method, microarray patches hold promise for self-administration, which could expand access to drug treatment and prevention strategies in a range of outpatient settings. Moreover, some patches could be
https://www.sciencedirect.com/science/article/pii/S0169409X12000282
The inflated reservoir exerts pressure delivery drug from the microarrays at a rate of 40 ng/day for 4 weeks . 4.2. Active delivery systems 4.2.1. Single reservoir active systems. Pumps generally include a drug reservoir, an actuator, and one or more valves in order to accurately control the delivery of small volumes of a drug in solution.Author: Cynthia L. Stevenson, John T. Santini, Robert Langer
https://pdfs.semanticscholar.org/b1a8/0b52cb722e4dfc3a6ae70510cba0a4fe9efc.pdf
Keywords: Transdermal Patch, Matrix Patches, Reservoir Type, Membrane Matrix , Drug-In-Adhesive Patches, Micro Reservoir Patches . INTRODUCTION . A transdermal patch is used to deliver a specific dose of medication through the skin and into bloodstream. Transdermal patches products were first approved in 1981 by FDA.
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