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https://www.sciencedirect.com/science/article/pii/S016836591101114X
Polymeric micelles (PM) system, as an efficient drug carrier, has received growing scientific attention in recent years owing to its solubilization, selective targeting, P-glycoprotein inhibition and altered drug internalization route and subcellular localization properties.Author: Jian Gong, Mei Wan (陳美婉) Chen, Ying (鄭穎) Zheng, Sheng Peng Wang, Yi Tao (王一濤) Wang
https://pubs.rsc.org/en/content/articlelanding/2019/tb/c8tb02255k
Abstract. Copolymers as a kind of drug delivery carrier always lack targeting efficiency. So a peptide conjugated to a drug delivery system has attracted much attention for tumor-targeted nanomedicine. Thus, we here report a conjugation compound consisting of a copolymer (PEG- b -PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7).Author: Qi Y. Wang, Hong M. Li, Zhi P. Dong, Bing X. Li, Ming Huo, Tao Lu, Yue Wang
https://www.hindawi.com/journals/jdd/2013/340315/
For oral drug delivery system, the block copolymers used to form micelles should (1) spontaneously self-assemble in water, (2) enhance drug solubility by several orders of magnitude and provide high loading efficiency, (3) remain stable upon dilution in the GI tract, (4) be biocompatible and nontoxic, and (5) be easy to synthesize at large scale [28, 56, 57].Author: Wei Xu, Peixue Ling, Tianmin Zhang
https://www.unmc.edu/pharmacy/faculty/pharmaceutical-sciences/docs/v5.pdf
One of the first reported examples of unimolecular micelles suitable for drug delivery was a threearm star polymer - composed of mucic acid substituted with fatty acids as a lipophilic inner block and PEO as a hydrophilic outer block.
http://www.eurekaselect.com/58294/article
Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes. An emphasis of this review has been placed on both the description and characterization techniques of the physical properties of polymeric micelles.
http://www.authorstream.com/Presentation/Omarmarwa-1404778-micelle-drug-delivery/
Apr 30, 2012 · APPLICATIONS Micelle increases bioavailability of poorly soluble drugs. Polymeric micelle is used to target the tumor site by passive as well as active mechanism. Micelle is used in ophthalmic drug delivery system, that effectively delivers the drug to posterior tissue of eyeball. Micelle is used to encapsulate the antibiotic & anticancer drugs.
https://www.researchgate.net/publication/323079036_Polymeric_Micelle_as_a_New_Carrier_in_Oral_Drug_Delivery_Systems
Polymeric micelles are one of the new nanocarriers which are able to increase the solubility of these drugs while protecting them from pH changes, dilution effect, and biological barriers such as filtration in the spleen or scavenging by the phagocytic system.
https://www.ncbi.nlm.nih.gov/pubmed/17168771
The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.Author: S. R. Croy, G. S. Kwon
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