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https://www.sciencedirect.com/topics/chemistry/micellar-drug
Micelle-forming substances have limited aqueous solubility, and when the free aqueous concentration reaches a certain point – the critical micelle concentration – typically in the millimolar range, micelles begin to form; further addition of the substance increases their abundance. With some compounds, as the density of micelles increases a gel is formed, consisting of a loosely packed array of micelles …
https://www.ncbi.nlm.nih.gov/pubmed/17168771
The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.Author: S. R. Croy, G. S. Kwon
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201237/
Micelles have been widely used as drug delivery carriers for a series of different molecules, including low molecular mass hydrophobic drugs, proteins, and genes [18–22]. Compared with other drug delivery strategies, micelles have two unmatched advantages. The first is their relatively small size.Author: Yang Lu, Ershuai Zhang, Jianhai Yang, Zhiqiang Cao
https://www.sciencedirect.com/topics/materials-science/micelle
Micelles are used for targeted drug delivery due to their high drug loading capacity, and opsonization of these micelles with sugar or peptide can also result in receptor-mediated targeted drug or gene delivery. pH and temperature-sensitive copolymers are used to develop intelligent vehicles, which are currently being used for achieving controlled release (Mourya et al., 2011). Intermolecular interaction among the block polymers leads to the formation of micelles…
https://pubs.rsc.org/en/content/articlelanding/2020/py/d0py00082e
The resulting drug-loaded micelles exhibit tunable drug loading capacity and excellent long-term drug-entrapment stability due to the strong affinity between the drug and micelle core, which led to highly efficient drug loading.Author: Chih-Chia Cheng, Ya-Ting Sun, Ai-Wei Lee, Shan-You Huang, Wen-Lu Fan, Yu-Hsuan Chiao, Chih-Wei Chiu,...
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