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https://www.sciencedirect.com/topics/medicine-and-dentistry/acidosis
Metabolic acidosis causes central nervous system depression less commonly. Fewer than 10% of diabetics with ketoacidosis develop coma (hyperosmolarity and the presence of acetoacetate may be more important than acidosis per se). Blood pH alters hemoglobin oxygen binding and tissue oxygen delivery.
https://www.ncbi.nlm.nih.gov/pubmed/9295823/
Effect of extreme metabolic acidosis on oxygen delivery capacity of the blood--an in vitro investigation of changes in the oxyhemoglobin dissociation curve in blood with pH values of approximately 6.30. Refsum HE(1), Opdahl H, Leraand S. Author information: (1)Institute for Respiratory Physiology, Ullevål University Hospital, Oslo, Norway.Author: Harald E. Refsum, Helge Opdahl, Severin Leraand
https://www.webmd.com/a-to-z-guides/what-is-metabolic-acidosis
Certain types of metabolic acidosis have a bigger difference -- or "gap" -- than others. Arterial blood gases . This test measures the pH of your blood and the levels of oxygen and carbon dioxide ...
https://todaysveterinarypractice.com/the-practitioners-acid-base-primer-differential-diagnoses-treatment/
In patients with increased anion gap (AG) metabolic acidosis, unmeasured organic anions, such as ketones or lactate, can be metabolized to HCO3- during recovery. If metabolic acidosis is due to lactate from hypovolemia, take appropriate measures—intravascular volume resuscitation using IV fluids—to restore adequate oxygen delivery to tissues.
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-019-2733-y
Mar 25, 2019 · Lactic acidosis with an elevated lactate–pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the microcirculation. To assess if there is an additional contribution to hyperlactataemia from relatively inadequate total oxygen delivery, oxygen consumption and delivery were ...Author: Hugh W. Kingston, Hugh W. Kingston, Hugh W. Kingston, Aniruddha Ghose, Voravut Rungpradubvong, Vorav...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534594/
Jul 30, 2015 · Lactic acidosis is a common cause of high anion gap metabolic acidosis [9, 25–27] and is classified as type A (anaerobic), which is associated with tissue hypoperfusion and denotes a condition of intact mitochondrial function but inadequate oxygen delivery (such as in shock states), or type B (aerobic), wherein oxygen supply is adequate and ...Author: Dimitrios Velissaris, Vasilios Karamouzos, Nikolaos Ktenopoulos, Charalampos Pierrakos, Menelaos Kar...
https://www.sciencedirect.com/topics/medicine-and-dentistry/metabolic-acidosis
Metabolic acidosis is the most common acid-base disorder recognized in domestic animals. Like in respiratory alkalosis (see Chapter 91), the bicarbonate buffer equation is shifted to the left in metabolic acidosis (Fig. 87-1).Also, with an excess acid load or decreased urinary acid excretion, either an increased or normal plasma AG can be seen (see Table 86-1).
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