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https://support.microsoft.com/en-ca/help/303734/how-to-configure-the-smtp-virtual-server-for-message-delivery
With a route domain, only messages for the remote domain are routed to a specific server. If you set up a smart host, you can still designate a different route for a remote domain. The route domain setting overrides the smart host setting. To set up a smart host, follow these steps: In the MMC, click to select the SMTP virtual server, and then ...
https://docs.microsoft.com/en-us/exchange/mail-flow-best-practices/remote-domains/manage-remote-domains
Feb 07, 2020 · Remote domains define settings based on the destination domain of each email message. All organizations have a default remote domain named "Default" that's applied to the domain "*". The default remote domain applies the same settings to all email messages regardless of the destination domain.
https://forums.asp.net/t/2105304.aspx?Message+delivery+to+the+host+some+IP+Like+failed+while+delivering+to+the+remote+domain+test+com+for+the+following+reason+The+remote+server+did+not+respond+to+a+connection+attempt+
Oct 10, 2016 · Message delivery to the host '[some IP Like]' failed while delivering to the remote domain 'test.com' for the following reason: The remote server did not respond to a connection attempt.
https://www.experts-exchange.com/questions/22955956/Message-delivery-to-the-host-'70-96-253-8'-failed-while-delivering-to-the-remote-domain-'cityofrochester-gov'-for-the-following-reason-The-connection-was-dropped-by-the-remote-host.html
Message delivery to the host '70.96.253.8' failed while delivering to the remote domain 'cityofrochester.gov' for the following reason: The connection was dropped by the remote host.
https://answers.microsoft.com/en-us/msoffice/forum/msoffice_o365admin-mso_dep365/smtp-relay-to-office-365-just-stopped-working-with/d3526796-749f-4d79-bb4f-61b780036010
May 14, 2016 · Message delivery to the host '132.245.44.226' failed while delivering to the remote domain '*****.com' for the following reason: The remote SMTP service rejected AUTH negotiation. We have not changed any TLS settings or enabled/disabled any ciphers in the past few months.
https://security.stackexchange.com/questions/29042/windows-system-event-log-warnings-for-smtpsvc
Message delivery to the remote domain 'particular domain or IP address' failed for the following reason: The remote server did not respond to a connection attempt I have locked down the smtp server, or at least I think I have - I also don't allow relaying.
https://answers.microsoft.com/en-us/msoffice/forum/msoffice_outlook/smtp-relay-failure-messages-stuck-in-queue-folder/ccb46120-683b-470d-9f83-fc57b525c963
Jul 19, 2017 · 5). Click Outbound Connections under Delivery tab, in TCP port filed, type 587. 6). Click Advanced under Delivery tab, under Smart host fled, type the SMTP server name. To find the SMTP server name, login as *** Email address is removed for privacy ***, and refer the following steps to check: Sign into OWA > Options > Mail > Accounts > POP and IMAP.
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