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https://www.sciencedirect.com/science/article/pii/S0168365905003974
Porous silicon (PSi) has some advantages compared to synthesised mesoporous materials when drug delivery vehicles are considered. The fabrication of PSi is a simple procedure, where the porosity and pore size can easily be tuned by anodization parameters .Depending on the morphology, PSi could be tailored as a biodegradable, bioactive or stable material , .Author: J. Salonen, L. Laitinen, A.M. Kaukonen, J. Tuura, M. Björkqvist, T. Heikkilä, K. Vähä-Heikkilä, J. H...
https://www.sciencedirect.com/science/article/abs/pii/S0168365905003974
Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drugs ... However, with poorly dissolving drugs, the loading into the mesoporous microparticles clearly improved dissolution. In addition, pH dependency of the dissolution was reduced when the drug substance was loaded into the microparticles.
https://pubs.acs.org/doi/10.1021/mp900221e
Surface functionalized mesoporous silicon (pSi) microparticles are reported as a solid dispersion carrier for improving dissolution and enhancing the orally administered pharmacokinetics (fasted rat model) of indomethacin (IMC), employed as a model poorly soluble BCS type II drug. IMC was loaded via immersion/solvent evaporation onto the thermally oxidized pSi particles, which provide a stable ...Author: Feng Wang, He Hui, Timothy J. Barnes, Christian Barnett, Clive A. Prestidge
https://pubs.acs.org/doi/10.1021/am403999q
A major challenge for a drug-delivery system is to engineer stable drug carriers with excellent biocompatibility, monodisperse size, and controllable release profiles. In this study, we used a microfluidic technique to encapsulate thermally hydrocarbonized porous silicon (THCPSi) microparticles within solid lipid microparticles (SLMs) to overcome the drawbacks accompanied by THCPSi ...Author: Dongfei Liu, Bárbara Herranz-Blanco, Ermei Mäkilä, Laura R. Arriaga, Sabiruddin Mirza, David A. Weit...
https://www.researchgate.net/publication/38052532_Oxidized_Mesoporous_Silicon_Microparticles_for_Improved_Oral_Delivery_of_Poorly_Soluble_Drugs
Oxidized Mesoporous Silicon Microparticles for Improved Oral Delivery of Poorly Soluble Drugs Article (PDF Available) in Molecular Pharmaceutics 7(1):227-36 · November 2009 with 349 Reads
https://www.researchgate.net/publication/7593394_Mesoporous_silicon_microparticles_for_oral_drug_delivery_Loading_and_release_of_five_model_drugs
Mesoporous silicon (PSi) microparticles were produced using thermal carbonization (TCPSi) or thermal oxidation (TOPSi) to obtain surfaces suitable for oral drug administration applications.
https://www.ncbi.nlm.nih.gov/pubmed/28969564
Examining Insulin Adsorption onto Mesoporous Silica Microparticles for Oral Delivery. Eilleia SY(1), Soliman ME(1), Niedermayer S(2), Schmidt A(2), Mansour S(1), Geneidi AS(1). Author information: (1)Department of Pharmaceutics and Industrial Pharmacy, Faculty of …Author: Sarah Youssef Eilleia, Mahmoud Eid Soliman, Stefan Niedermayer, Alexandra Schmidt, Samar Mansour, Ah...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842076/
The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes.Author: A. Jiménez-Periáñez, B. Abos Gracia, J. López Relaño, C. M. Diez-Rivero, P. A. Reche, E. Martínez-Na...
https://reference.medscape.com/medline/abstract/28969564
Examining Insulin Adsorption onto Mesoporous Silica Microparticles for Oral Delivery. Curr Drug Deliv. 2018; 15(4):541-553 ... The present work displays the various factors that can control insulin loading in mesoporous silica MPs and their effects in enhancing the efficiency of insulin oral delivery using such substrates. ... (Silicon Dioxide ...
https://link.springer.com/article/10.1007/s10973-005-0666-x
May 01, 2005 · Thermally carbonised mesoporous silicon microparticles were produced and loaded with two active pharmaceutical ingredients, ibuprofen and antipyrine. By combining the results measured with TG and DSC, reliable estimations for the degrees of the drug loads were obtained.Author: V.-P. Lehto, K. Vähä-Heikkilä, J. Paski, J. Salonen
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