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https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.18-0024
The development of mesenchymal stem cells (MSCs) as cell‐based drug delivery vectors for numerous clinical indications, including cancer, has significant promise. However, a considerable challenge for effective translation of these approaches is the limited tumor tropism and broad biodistribution observed using conventional MSCs, which raises concerns for toxicity to nontarget …
https://www.sciencedirect.com/science/article/pii/S0168365918307223
Mesenchymal stem cells as a promising approach for gene or drug delivery Initially MSCs are found at bone marrow and presented various tissues afterwards [ 54 ]. In current studies, MSCs, stemmed from bone marrow (BM-MSCs), umbilical cord (UC-MSCs) and adipose tissue (AT-MSCs) are commonly used in researches and clinical trials [ [55] , [56] , [57] ].Author: Hong-Hui Wu, Yi Zhou, Yasuhiko Tabata, Jian-Qing Gao
https://www.ncbi.nlm.nih.gov/pubmed/30070053
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for numerous clinical indications, including cancer, has significant promise. However, a considerable challenge for effective translation of these approaches is the limited tumor tropism and broad biodistribution observed using conventional MSCs, which raises concerns for toxicity to nontarget …Author: Timothy E. G. Krueger, Daniel L. J. Thorek, Samuel R. Denmeade, John T. Isaacs, W. Nathaniel Brennen
http://www.eurekaselect.com/111736/article
Keywords: Cancer therapy, drug delivery, mesenchymal stem cells. Abstract: Self renewal, extensive proliferation and multilineage differentiation ability in vitro and in vivo make mesenchymal stem cells (MSCs) powerful tools for tissue engineering. Beyond their potential uses in regenerative medicine,...
https://www.ncbi.nlm.nih.gov/pubmed/23688246
Mesenchymal stem cells for anti-cancer drug delivery. Gjorgieva D(1), Zaidman N, Bosnakovski D. Author information: (1)Faculty of Medical Sciences, University Goce Delcev Stip, Krste Misirkov bb, 2000 Stip, R. Macedonia.Author: Darinka Gjorgieva, Nathan A. Zaidman, Darko Bosnakovski
https://www.researchgate.net/publication/236922540_Mesenchymal_Stem_Cells_for_Anti-Cancer_Drug_Delivery
Mesenchymal stem cells (MSCs) have inherent tumor-tropic and migratory properties, which allow them to serve as vehicles for targeted drug delivery systems for isolated tumors and metastatic...
https://www.nature.com/articles/s41573-020-0064-x
Fig. 2: Tumour-tropism of stem cells can be leveraged to enhance targeted drug delivery to hard-to-reach tumours and sites of metastases. Fig. 3: Gene editing to create universally ...
https://www.europepmc.org/articles/PMC3711684/
Europe PMC is an archive of life sciences journal literature. Find the latest peer-reviewed research articles and preprints on Coronavirus here.
https://www.sciencedirect.com/science/article/pii/S0169409X12002128
At present, the only human cell type known to have a scalable capacity to mass produce exosomes is MSC. MSC also has several cellular characteristics that are highly desired attributes of drug delivery vehicles. Therefore, MSC is the ideal cell candidate for the mass production of exosomes for drug delivery.Author: Ronne Wee Yeh Yeo, Ronne Wee Yeh Yeo, Ruenn Chai Lai, Bin Zhang, Soon Sim Tan, Yijun Yin, Bao Ju Teh...
https://cen.acs.org/business/start-ups/Meet-exosome-rising-star-drug/96/i31
3 days ago · Meet the exosome, the rising star in drug delivery Companies are hoping to use the vesicles to package small-molecule, protein, and RNA drugs …
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