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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · INTRODUCTION. Basically gene therapy is an intracellular delivery of genomic materials (transgene) into specific cells to generate a therapeutic effect by correcting an existing abnormality or providing the cells with a new function.[] Different types of gene delivery systems may be applied in gene therapy to restore a specific gene function or turning off a special gene(s).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480422/
Mar 13, 2017 · Polymeric Nanoparticles for Receptor-Mediated Gene Delivery to Lung Cancer. Targeting of nanoparticle-based gene delivery systems has been explored for improved uptake of nucleic acid therapeutics at the tumor site and to prevent undesirable off-target effects in healthy tissues.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
https://www.nature.com/articles/3302180
Feb 19, 2004 · EG-mediated gene delivery revealed higher and more prolonged mRNA expression levels of plasmid DNA in the blood until 9 days after the single intravenous injection. Moreover, plasmid DNA …Author: H. M. Byun, D. Suh, H. Yoon, J. M. Kim, H. G. Choi, Won-Ki Kim, J. J. Ko, Y. K. Oh
https://www.sciencedirect.com/science/article/pii/S1742706119305471
To address these obstacles, a variety of nonimmunogenic polymers are utilized to modify Ad vectors chemically or physically. In this review, we systemically discuss the functions of polymers in Ad-mediated gene delivery from two aspects: evading the host immune responses to Ads and redirecting Ad tropism.Author: Yanping Sun, Xiaoqian Lv, Pingtian Ding, Long Wang, Long Wang, Yongjun Sun, Shuo Li, Huimin Zhang, Z...
https://www.sciencedirect.com/science/article/pii/S0144861715009091
The purpose of this study was to evaluate receptor-mediated gene delivery into human mesenchymal stem cells (hMSCs) using HA-modified nanogels. There are a few studies of the use of nanogels harboring ligands of specific receptors to deliver genes into stem cells ( Levett et al., 2014 ).Author: Ji Sun Park, Se Won Yi, Hye Jin Kim, Keun-Hong Park
http://www.nature.com/articles/3301407
Apr 18, 2001 · Receptor-mediated gene delivery to human peripheral blood mononuclear cells using anti-CD3 antibody coupled to polyethylenimine Skip to main content Thank you for visiting nature.com.Author: MM O'Neill, CA Kennedy, RW Barton, RJ Tatake
https://directorsblog.nih.gov/tag/aav-mediated-gene-delivery/
AAV-mediated gene delivery. Snapshots of Life: Lighting up the Promise of Retinal Gene Therapy. Posted on November 10th, 2016 by Dr. Francis Collins. Caption: Large-scale mosaic confocal micrograph showing expression of a marker gene (yellow) transferred by gene therapy techniques into the ganglion cells (blue) of a mouse retina.
https://www.hindawi.com/journals/jdd/2011/326497/
The use of a cation is a recurring theme for virtually all chemically mediated gene delivery vectors, including polymers, lipids, and nondegradable nanoparticles. Between 8–18 carbons commonly comprise the hydrocarbon tails of lipids used for gene delivery. The tails are typically saturated, but a single double bond is occasionally seen.Author: Daniel A. Balazs, Wt. Godbey
https://stm.sciencemag.org/content/9/390/eaal3128.full
May 17, 2017 · Collectively, these findings demonstrate that ultrasound-mediated gene delivery to endogenous mesenchymal progenitor cells can effectively treat nonhealing bone fractures in large animals, thereby addressing a major orthopedic unmet need …Author: Maxim Bez, Maxim Bez, Dmitriy Sheyn, Wafa Tawackoli, Pablo Avalos, Galina Shapiro, Joseph C. Giaconi...
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