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https://www.sciencedirect.com/science/article/pii/S0301562906014621
Mechanism of intracellular delivery by acoustic cavitation. ... Drug delivery methods need improvement to increase drug and gene efficacy by enhancing intracellular delivery and to increase drug safety by targeting specific cells or organs to reduce side effects. Enhanced and targeted delivery methods are both limited by insufficient or ...Author: Robyn K. Schlicher, Robyn K. Schlicher, Harish Radhakrishna, Timothy P. Tolentino, Robert P. Apkaria...
https://www.researchgate.net/publication/6998964_Mechanism_of_intracellular_delivery_by_acoustic_cavitation
Indeed, one of the initial rational for this work was that US-induced cavitation would enhance the intracellular delivery of drugs by transiently increasing the cell membrane permeability 39. The ...
https://www.sciencedirect.com/science/article/abs/pii/S0301562906014621
Mechanism of intracellular delivery by acoustic cavitation. ... suggesting a ubiquitous mechanism of action. To determine the mechanism of these effects, we examined cells exposed to ultrasound by flow cytometry coupled with electron and fluorescence microscopies. The results show that cavitation generated by ultrasound facilitates cellular ...Author: Robyn K. Schlicher, Robyn K. Schlicher, Harish Radhakrishna, Timothy P. Tolentino, Robert P. Apkaria...
https://www.semanticscholar.org/paper/Mechanism-of-intracellular-delivery-by-acoustic-Schlicher-Radhakrishna/45517e2e049781bfd58d12e354d058791f822fc1
Mechanism of intracellular delivery by acoustic cavitation. @article{Schlicher2006MechanismOI, title={Mechanism of intracellular delivery by acoustic cavitation.}, author={Robyn K. Schlicher and Harish Radhakrishna and Timothy P. Tolentino and Robert P. Apkarian and Vladimir G. Zarnitsyn and Mark R. Prausnitz}, journal={Ultrasound in medicine ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918399/
The field of ultrasound (US) has changed significantly from medical imaging and diagnosis to treatment strategies. US contrast agents or microbubbles (MB) are currently being used as potential carriers for chemodrugs, small molecules, nucleic acids, small interfering ribonucleic acid, proteins, adenoviruses, and oncolytic viruses.Author: Rounak Nande, Candace M Howard, Pier Paolo Claudio
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074498/
May 07, 2008 · These observations are consistent with a mechanism that suggests that ultrasound is capable of stimulating the intracellular delivery of therapeutic molecules via non-porative mechanisms. Therefore, non-cavitational adjunctive ultrasound offers a novel paradigm in intracellular cargo delivery from PFC nanoparticles.Author: N. R. Soman, J. N. Marsh, Gregory Lanza, S. A. Wickline
http://drugdelivery.chbe.gatech.edu/Papers/2006/Schlicher%20Ultrasound%20in%20Med%20&%20Biol%202006.pdf
Original Contribution MECHANISM OF INTRACELLULAR DELIVERY BY ACOUSTIC CAVITATION ROBYN K. SCHLICHER,*† HARISH RADHAKRISHNA,‡ TIMOTHY P. TOLENTINO,* ROBERT P. APKARIAN,§ VLADIMIR ZARNITSYN,† and MARK R. PRAUSNITZ,*† *The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, GeorgiaAuthor: Robyn K. Schlicher, Robyn K. Schlicher, Harish Radhakrishna, Timothy P. Tolentino, Robert P. Apkaria...
http://drugdelivery.chbe.gatech.edu/publications.html
RK Schlicher, H Radhakrishna, TP Tolentino, RP Apkarian, V Zarnitsyn, MR Prausnitz (2006) Mechanism of intracellular delivery by acoustic cavitation, Ultrasound in Medicine and Biology, 32:915-924. [PubMed link] JH Park, MG Allen, MR Prausnitz (2006) Polymer microneedles for controlled-release drug delivery, Pharmaceutical Research, 23:1008-1019.
https://www.researchgate.net/publication/234050525_Mechanisms_of_the_Ultrasound-Mediated_Intracellular_Delivery_of_Liposomes_and_Dextrans
Mechanisms of the Ultrasound-Mediated Intracellular Delivery of Liposomes and Dextrans Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control 60(1):21-33 · January ...
https://www.nature.com/articles/s42254-019-0074-y
Jun 17, 2019 · This Review describes how acoustic cavitation can be used to improve the delivery of drugs for the treatment of diseases such as cancer and stroke. Methods for …Author: Eleanor Stride, Constantin Coussios
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