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https://www.annualreviews.org/doi/10.1146/annurev.matsci.31.1.25
Non-viralbased gene therapy provides a relatively safe approach to increase or decrease the expression of a specific gene using DNA or antisense sequences; however, synthetic systems are required to direct plasmids and oligonucleotides to a specific tissue and to enhance cellular uptake and intracellular trafficking.Author: Tatiana Segura, Lonnie D. Shea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · In this review we explain about the history of gene therapy, all types of gene delivery systems for germline (nuclei, egg cells, embryonic stem cells, pronuclear, microinjection, sperm cells) and somatic cells by viral [retroviral, adenoviral, adeno association, helper-dependent adenoviral systems, hybrid adenoviral systems, herpes simplex, pox virus, lentivirus, Epstein–Barr virus)] and nonviral systems …
https://ui.adsabs.harvard.edu/abs/2001AnRMS..31...25S/abstract
The development of synthetic delivery systems to manipulate gene expression efficiently is a powerful tool that will ultimately lead to novel therapeutic strategies for the treatment of numerous disorders. Now on home page ... Materials for Non-Viral Gene Delivery Segura, Tatiana; ...Author: Tatiana Segura, Lonnie D. Shea
https://www.researchgate.net/publication/249558418_Materials_for_Non-Viral_Gene_Delivery
Abstract Chitosan as a polycationic non-viral vector for gene delivery has the advantage of being a biocompatible and biodegradable polymer. However, without laborious chemical modifications to its...
https://www.nature.com/articles/natrevmats201756
Sep 12, 2017 · Van Tendeloo, V. F. I. Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid ...Author: Khalid A. Hajj, Kathryn A. Whitehead
https://www.nature.com/articles/s41570-018-0039-1
Sep 21, 2018 · Chemistry has a key role in the development of innovative synthetic materials to overcome the challenges of producing next-generation gene delivery therapies and protocols. In this Review, we discuss the latest chemical advances in the production of materials for the delivery of nucleic acids to cells and for gene therapy.Author: Irene Lostalé-Seijo, Javier Montenegro
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Since the initial studies, hundreds of cationic lipids have been synthesized as candidates for non-viral gene delivery and a few made it to clinical trials [85,86]. Cationic lipids can be used to form lipoplexes by directly mixing the positively charged lipids at the physiological pH with the negatively charged DNA.Author: Alicia Rodríguez Gascón, Ana del Pozo-Rodríguez, María Ángeles Solinís
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The non-viral vectors are Naked DNA, particle based and chemical based. They are administered by direct administration (plasmid DNA/Naked DNA)/ chemical /physical. Most of cardiovascular clinical trials use non-viral vectors as a mode of gene transfer.Author: Murali Ramamoorth, Aparna Narvekar
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