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https://www.cmeinstitute.com/Psychlopedia/Pages/depression/18umpc/sec4/section.aspx
Transdermal Delivery System. Although simplified over the years, the dietary restrictions for MAOI use have been perceived by patients and clinicians as difficult to manage. One effort to improve the safety of MAOIs and limit or avoid the need for dietary restrictions was the development of the transdermal delivery system for selegiline.
https://www.ncbi.nlm.nih.gov/pubmed/22951239
The transdermal delivery system of monoamine oxidase inhibitors. VanDenBerg CM(1). Author information: (1)Department of Pharmacy Practice and Center for Clinical Research, Mercer University College of Pharmacy and Health Sciences, Atlanta, GA, USA. [email protected]: Chad M. VanDenBerg
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200016/
Oct 06, 2014 · The EMSAM patch is a unique monoamine oxidase inhibitor (MAOI) being the only antidepressant utilizing a transdermal delivery system. This was welcomed by clinicians who hoped that EMSAM would be better tolerated than oral MAOIs and non-MAOI antidepressants, as well as being effective for treatment in a wide spectrum of depressed patients including atypical depression, bipolar …Author: Gregory M Asnis, Margaret A Henderson
https://www.researchgate.net/publication/232713790_The_Transdermal_Delivery_System_of_Monoamine_Oxidase_Inhibitors
The infrequent use of MAOIs stems from the perception that other oral therapies for depression are safer and easier to use than oral MAOIs; however, transdermal delivery is one potential strategy ...Author: Chad Vandenberg
https://www.researchgate.net/publication/296528608_Transdermal_selegiline_A_new-generation_MAOI
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https://www.cmeinstitute.com/Psychlopedia/Pages/depression/18umpc/sec5/section.aspx
(For an in-depth review of the mechanism of action of MAOIs, see "MAOIs and Transdermal Delivery" by Chad M. VanDenBerg, PharmD, BCPP. 3) Selectivity of MAOIs. The 2 isomers of MAO enzymes are MAO-A and MAO-B.
https://www.psychologytoday.com/sites/default/files/the_use_of_transdermal_therapeutic_systems_final.pdf
Transdermal delivery (i.e., patches) for medicines with ... oral MAOIs, particularly those relating to dietary constraints.121 Monoamine oxidase (MAO) in the gastrointesti-
https://www.sciencedirect.com/science/article/pii/S0278584607001546
Aug 15, 2007 · Currently available evidence suggests that STS (6 mg/24 h, 9 mg/24 h, and 12 mg/24 h) is effective in both short-term and long-term treatments of patients with MDD, particularly those who would benefit the most from MAOIs. Importantly, transdermal delivery facilitates the antidepressant properties without the need for dietary restrictions of ...Author: Chi Un Pae, Chi Un Pae, Hyun Kook Lim, Changsu Han, Changsu Han, Ajwani Neena, Chul Lee, Ashwin A. P...
https://www.medscape.org/viewarticle/553319_2
Oct 13, 2019 · The transdermal system is formulated to release a constant amount of drug over a 24-hour period. What you see is something in between the oral and the intravenous profile, and you see relatively sustained concentrations during this period of time. N-Desmethylselegiline Plasma Concentration Versus Time by Mode of Delivery:
https://www.sciencedirect.com/science/article/pii/S0033318210706794
The primary advantage of its transdermal delivery is its bypassing of the gastrointestinal system, thereby limiting the chances of a hypertensive crisis caused by intake of tyramine-rich foods. At the 6 mg/24 hr. dose, transdermal selegiline has minimal effect on MAO A, and there need be no dietary restrictions. At the 9 mg/24 hr. dose or ...Author: Pamela J. Horn, Irving M Reti, Geetha Jayaram
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