Mannan-Modified Plga Nanoparticles For Targeted Gene Delivery

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Mannan-Modified PLGA Nanoparticles for Targeted Gene Delivery

    https://www.hindawi.com/journals/ijp/2012/926754/
    The studies of targeted gene delivery nanocarriers have gained increasing attention during the past decades. In this study, mannan modified DNA loaded bioadhesive PLGA nanoparticles (MAN-DNA-NPs) were investigated for targeted gene delivery to the Kupffer cells (KCs). Bioadhesive PLGA nanoparticles were prepared and subsequently bound with pEGFP</i>.Author: Fansheng Kong, Linfu Ge, Ximin Liu, Ning Huang, Fang Zhou

Mannan-Modified PLGA Nanoparticles for Targeted Gene Delivery

    https://www.researchgate.net/publication/258388735_Mannan-Modified_PLGA_Nanoparticles_for_Targeted_Gene_Delivery
    The studies of targeted gene delivery nanocarriers have gained increasing attention during the past decades. In this study, mannan modified DNA loaded bioadhesive PLGA nanoparticles (MAN-DNA-NPs ...

Novel Mannan-PEG-PE Modified Bioadhesive PLGA ...

    https://www.hindawi.com/journals/jnm/2012/981670/
    Purpose . Biodegradable polymeric nanoparticles have been used frequently as gene delivery vehicles. The aim of this study is to modify bioadhesive PLGA nanoparticles with novel synthetic mannan-PEG-PE (MN-PEG-PE) to obtain active targeted gene delivery system. Methods . Mannan-PEG-PE ligands were synthesized and modified onto the NPs/pEGFP complexes.Author: Guicun Wu, Fang Zhou, Linfu Ge, Ximin Liu, Fansheng Kong

Novel mannan-PEG-PE modified bioadhesive PLGA ...

    https://dl.acm.org/doi/10.1155/2012/981670
    Purpose. Biodegradable polymeric nanoparticles have been used frequently as gene delivery vehicles. The aim of this study is to modify bioadhesive PLGA nanoparticles with novel synthetic mannan-PEG-PE (MN-PEG-PE) to obtain active targeted gene delivery system.Author: WuGuicun, ZhouFang, GeLinfu, LiuXimin, KongFansheng

Mannan-Modified PLGA Nanoparticles for Targeted Gene Delivery

    http://core.ac.uk/display/29439924
    Abstract. The studies of targeted gene delivery nanocarriers have gained increasing attention during the past decades. In this study, mannan modified DNA loaded bioadhesive PLGA nanoparticles (MAN-DNA-NPs) were investigated for targeted gene delivery to the Kupffer cells (KCs).

Mannan-Modified Solid Lipid Nanoparticles for Targeted ...

    https://link.springer.com/article/10.1007%2Fs11095-010-0149-z
    Apr 27, 2010 · When compared with non-modified SLN-DNA and Lipofectamine 2000-DNA, Man-SLN-DNA produced the highest gene expressions, especially in vivo. These results demonstrated the active targeting ability of this kind of mannan-modified DNA-loaded vehicles, which may have great potential for targeted gene delivery.Author: Wangyang Yu, Chunxi Liu, Yu Liu, Na Zhang, Wenfang Xu

Mannan-Modified Solid Lipid Nanoparticles for Targeted ...

    https://www.researchgate.net/publication/43346454_Mannan-Modified_Solid_Lipid_Nanoparticles_for_Targeted_Gene_Delivery_to_Alveolar_Macrophages
    Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages Article in Pharmaceutical Research 27(8):1584-96 · August 2010 with 64 Reads How we measure 'reads'

Targeting of tumor-associated macrophages made possible by ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946577/
    Sep 03, 2013 · It is increasingly evident that tumor-associated macrophages (TAMs) play an important role in tumor invasion, proliferation, and metastasis. While delivery of drugs, imaging agents and vaccines to TAMs was achieved by exploiting membrane receptors on TAMs, the uptake by normal macrophages remains an issue.Author: Saijie Zhu, Mengmeng Niu, Hannah O'Mary, Zhengrong Cui

Co-delivery of plasmid DNA and doxorubicin by solid lipid ...

    https://www.spandidos-publications.com/10.3892/ijmm.2014.1770
    The co-delivery of DNA and antitumor drugs has the potential to treat cancer. In this study, we aimed to develop surface-modified, co-encapsulated solid lipid nanoparticles (SLN) containing enhanced green fluorescence protein plasmid (pEGFP) and doxorubicin (DOX) in order to create a multifunctional delivery system that targets lung cancer cells, in an effort to improve the efficacy of cancer ...Author: Yiqun Han, Peng Zhang, Yuanyuan Chen, Jiping Sun, Fansheng Kong

Mannosylated liposomes for targeted gene delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289440/
    Introduction. Gene delivery using nonviral pharmaceutical vectors has long been considered, because these vectors are less toxic, less immunogenic, and easily modified.1–3 Nonviral carriers, such as polymeric nanoparticles,4 liposomes,5 micelles,6 nanocapsules,7 solid lipid nanoparticles,8 niosomes,9 and other vectors have been widely used as gene delivery systems.

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