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https://www.ncbi.nlm.nih.gov/pubmed/23289618
INTRODUCTION: Targeted drug delivery to the macrophages appears to be an attractive proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.Author: Narendra K Jain, Vijay Mishra, Neelesh Kumar Mehra
https://www.sciencedirect.com/science/article/abs/pii/S0169409X1930239X
Here, we discuss the role of macrophages in the initiation and progression of various inflammatory diseases, summarize the leading drugs used to regulate macrophages, and review drug delivery systems designed to target macrophages. We emphasize strategies that are approved for clinical use or are poised for clinical investigation.Author: Wei He, Wei He, Wei He, Neha Kapate, Neha Kapate, Neha Kapate, C. Wyatt Shields, C. Wyatt Shields, S...
https://www.sciencedirect.com/science/article/pii/S0169409X1930239X
Accordingly, drugs and drug delivery strategies that target macrophages are gaining traction as a means to treat IDs. In general, two strategies are used, those that target: (i) extracellular signals secreted by, or intended for, macrophages and (ii) receptors on, or within, macrophages.Author: Wei He, Wei He, Wei He, Neha Kapate, Neha Kapate, Neha Kapate, C. Wyatt Shields, C. Wyatt Shields, S...
https://www.researchgate.net/publication/264232932_Macrophages_Targeted_Drug_Delivery_as_a_Key_Therapy_in_Infectious_Disease
Macrophages Targeted Drug Delivery as a Key Therapy in Infectious Disease. ... Macrophages T argeted Drug Delivery as a Key . ... macrophage-targeted therapy for several reasons.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073303/
Jul 04, 2018 · Liposomes, self-closed structures characterized by one or more phospholipid bilayers delimiting an inner aqueous space, were developed many years ago, and soon after demonstrated their great potential as vehicles for drug delivery [63,64,65]. Since their discovery more than 50 years ago, they have been a matter of extensive investigation ...Author: Mirco Ponzoni, Fabio Pastorino, Daniela Di Paolo, Patrizia Perri, Chiara Brignole
https://www.hindawi.com/journals/jdd/2011/727241/
Efficient methods of targeting these cells can facilitate efficient drug delivery but also potentially facilitate cell activation and ablation. The properties of liposomes mean they naturally target cells of the MPS, particularly macrophages. This natural targeting capacity can be harnessed for drug delivery.Author: Ciara Kelly, Caroline Jefferies, Sally-Ann Cryan
https://www.researchgate.net/publication/51069702_Targeted_Liposomal_Drug_Delivery_to_Monocytes_and_Macrophages
The goal for targeting monocytes/macrophages using liposomes includes not only drug delivery but also potentially a role in cell ablation and cell activation for the treatment of conditions ...
http://researchpub.org/journal/bmbn/number/vol2-no1/vol2-no1-5.pdf
argeted drug delivery of the mononuclear-phagocytic system cells has been long time considered to be an attractive strategy of treatment of infectious disease produced by specific pathogenic microorganisms. This is due to the fact that macrophages and dendritic cells are the main or alternative ...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1567-2018&volume=2&issue=4&spage=311
Moreover, macrophages upon interaction with particulate drug delivery vehicles may act as secondary drug depot, thus helping in localized delivery of the drug at the infected site. In the present article, a comprehensive review of literature is presented on the suitability of some lipid-based and polymeric materials as vehicles in delivery of ...
https://bioengineeringcommunity.nature.com/users/108489-christopher-rodell/posts/33422-re-educating-tumor-macrophages-for-immunotherapy
Cyclodextrin nanoparticles for macrophage-targeted drug delivery improve cancer immunotherapy when paired with potent immunostimulatory drugs. Cyclodextrin nanoparticles for macrophage-targeted drug delivery improve cancer immunotherapy when paired with potent immunostimulatory drugs. Menu.Author: Christopher Rodell
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