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https://www.researchgate.net/profile/William_Saltzman/publication/12689680_Synthetic_DNA_delivery/links/557c49cf08aec87640db4c53.pdf
Current synthetic DNA delivery systems are versatile and safe, but substantially less efficient than viruses. Indeed, most current systems address only one of the obsta-
https://kf.tuzvo.sk/sites/default/files/FG10-4_282.pdf
SYNTHETIC DNA DELIVERY SYSTEMS Synthetic DNA Delivery Systems, D. Luo & W.M. Saltzman (eds.), Kluwer Academic /Plenum Publishers, New York, 2003, 135 pp., hardcover, ISBN 0-306-47701 -7, $138.00 This excellently produced and well illustrated work is the seventh volume in the series called Biotechnology Intelligence Unit.
http://europepmc.org/abstract/MED/10625387
Toward this end, rapid advances have recently been made in our understanding of mechanisms for DNA stability and transport within cells. Current synthetic DNA delivery systems are versatile and safe, but substantially less efficient than viruses. Indeed, most current systems address only one of the obstacles to DNA delivery by enhancing DNA uptake.
https://bee.cals.cornell.edu/people/dan-luo/
Dan Luo is a Professor in the Department of Biological and Environmental Engineering. He works with DNA and RNA as both generic and genetic materials.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751499/
This review discusses the basis of structural design, mode of action, and applications of DNA-based therapeutics. The mechanisms of cellular uptake and intracellular trafficking of DNA-based therapeutics are examined, and the constraints these transport processes impose on the choice of delivery systems are summarized.
https://link.springer.com/protocol/10.1385%2F1-59259-141-8%3A083
Abstract. For in vivo gene transfer, synthetic (nonviral) vectors are thought to have several advantages compared with viral vectors: they can accommodate largesize DNA molecules (therapeutic genes including their endogenous regulatory regions), be used under reduced confinement conditions, be administered repeatedly, and be modified with appropriate ligands that allow specific cell targeting.
https://pubs.acs.org/doi/10.1021/nn4012384
Multifunctional membrane-core nanoparticles, composed of calcium phosphate cores, arginine-rich peptides, cationic and PEGylated lipid membranes, and galactose targeting ligands, have been developed as synthetic vectors for efficient nuclear delivery of plasmid DNA and subsequent gene expression in hepatocytes in vivo. Targeted particles exhibited rapid and extensive hepatic …
https://www.intechopen.com/books/recent-advances-in-novel-drug-carrier-systems/gene-delivery-systems-recent-progress-in-viral-and-non-viral-therapy
Gene Delivery Systems: Recent Progress in Viral and Non-Viral Therapy. ... A synthetic gene delivery system: [1] should protect the negatively-charged phosphate DNA skeleton against anionic cell surface from load repulsion, [2] should be condensed to suitable length intervals of DNA with a macromolecular structure for cellular internalization ...
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202002915
All‐DNA scaffolds act as templates for the organization of photosystem I model systems. A series of DNA templates composed of Zn II ‐protoporphyrin IX (Zn II PPIX)‐functionalized G‐quadruplex conjugated to the 3′‐ or 5′‐end of the tyrosinamide (TA) aptamer and Zn II PPIX/G‐quadruplex linked to the 3′‐ and 5′‐ends of the TA aptamer through a four‐thymidine bridge.
https://science.sciencemag.org/content/355/6329/eaaf3981.full
The same synthetic rDNA unit was also used to regenerate rDNA at three distinct chromosomal locations. The rDNA signature sequences of the internal transcribed spacer (ITS), often used to determine species identity by standard DNA barcoding procedures, were swapped to generate a Saccharomyces synXII strain that would be identified as S. bayanus.
https://www.sciencedirect.com/science/article/pii/S0169409X10000736
2. Linear DNA. The specificity of hybridisation makes DNA ideal for nanoscale systems that require molecular recognition. There are a variety of systems that take advantage of the hybridisation of linear DNA for nanomedicine applications, including oligonucleotide sensing, multiplexed pathogen detection, aptameric drug delivery and diagnostics, as well as stimuli-responsive hydrogels.
https://www.sciencedirect.com/science/article/pii/S1818087614000725
A review on phospholipids and their main applications in drug delivery systems ... The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems, and highlight the relationship between the properties and applications, and the effect of the species of phospholipids on the efficiency of drug ...
http://nusc.uconn.edu/people-faculty-luo.php
The major research focus of Dr. Luo’s laboratory is to utilize nanotechnology-based techniques to develop biocompatible, biodegradable, and non-toxic nanoscale delivery systems for nutrients. In particular, Dr. Luo’s laboratory studies the physical and chemical interactions among food biomaterials at nanoscale to fabricate various delivery ...
https://www.nature.com/articles/nature02388
Biomaterials have played an enormous role in the success of medical devices and drug delivery systems. We discuss here new challenges and directions in biomaterials research. These include ...
https://www.addgene.org/Minmin_Luo/
The Minmin Luo Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a nonprofit plasmid repository dedicated to improving life science research. Learn more about research in the Minmin Luo Lab.
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