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http://www.authorstream.com/Presentation/sagarpharmavision-1202382-importance-of-partition-coefficient-in-formulation-development/
Sep 25, 2011 · Importance of Partition Coefficient in Formulation Development - authorSTREAM Presentation. Slide 2: The partition coefficient The lipophilicity of an organic compound is usually described in terms of a partition coefficient, log p, which can be defined as the ratio of the concentration of the unionized compound, at equilibrium, between organic and aqueous phases: Log P values have …
https://en.wikipedia.org/wiki/Partition_coefficient
The partition coefficient, abbreviated P, is defined as a particular ratio of the concentrations of a solute between the two solvents (a biphase of liquid phases), specifically for un-ionized solutes, and the logarithm of the ratio is thus log P.: 275ff When one of the solvents is water and the other is a non-polar solvent, then the log P value is a measure of lipophilicity or hydrophobicity.
https://www.cognibrain.com/pharmaceutical-formulations/
A drug formulation can be given to the patient in various forms like solid, semisolid or liquid. The type of the formulation given depends upon the patient’s age, sex, and health condition and is specific for particular routes of administration. Here we give a brief overview of the different forms of …
http://www.pharmtech.com/four-challenges-pulmonary-drug-delivery
Sep 01, 2017 · Pulmonary drug delivery is becoming increasingly used. When developing pulmonary drugs, pharmaceutical chemists must consider drug absorption, control of particle size, suitable toxicology models, and patient compliance. The author reviews the issues specific to developing drugs designed for pulmonary delivery and considers how—with the right knowledge and expertise—these challenges …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850451/
The tablet was coated with an impermeable backing layer of ethyl cellulose to ensure unidirectional drug release. Different penetration enhancers were tried to improve the permeation of pravastatin sodium through buccal mucosa. Formulation containing 1% sodium lauryl sulfate showed good permeation of pravastatin sodium through mucosa.Author: Supriya S. Shidhaye, Pritesh V. Thakkar, Neha M. Dand, Vilasrao J. Kadam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425796/
Aug 12, 2012 · Designing Paclitaxel Drug Delivery Systems Aimed at Improved Patient Outcomes: Current Status and Challenges. ... It is a highly lipophilic compound with a log P value of 3.96 and very poor aqueous solubility of less than 0.01 mg/mL. In addition, the compound lacks functional groups that are ionizable which could potentially lead to an increase ...Author: Madhu S. Surapaneni, Sudip K. Das, Nandita G. Das
https://www.mdpi.com/2079-4983/9/1/11/pdf
major emphasis on “smart” drug carriers developed with poloxamers. The diverse range of potential delivery methods is highlighted in this review by discussing how the poloxamer solution behavior enables multiple formulation processing routes, drug-encapsulating structures, and engagement with physiological barriers to drug passage.Author: Andrew M. Bodratti, Paschalis Alexandridis
https://www.sciencedirect.com/science/article/pii/S1818087613000135
The lymphatic system that extends throughout the whole body is one of useful targets for efficient drug delivery. The intestinal lymphatic drug delivery has been actively studied to date because administered drugs can avoid the first-pass metabolism in the liver, resulting in improvement of oral bioavailability.Author: Hyeongmin Kim, Yeongseok Kim, Jaehwi Lee
https://www.ondrugdelivery.com/the-science-of-solubility-and-the-success-of-amorphous-solid-dispersions/
Stage of drug development where formulation is required: At the early stages of drug development (preclinical and before), availability of limited drug quantities and constraint of time and money necessitate that a simple, reproducible and physico-chemically stable formulation is developed. From Phase I onwards, a more in-depth study is possible and various formulation strategies could be ...
https://www.researchgate.net/publication/26285678_Recent_Trends_in_Oral_Drug_Delivery_A_Review
Recent Trends in Oral Drug Delivery: A Review ... Ropinirole was selected as a model lipophilic drug for this purpose (Log P = 3.32). These systems often require high surfactant concentration, and ...
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