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https://www.sciencedirect.com/science/article/pii/S177322471250002X
However, the delivery of siRNA after local injection could represent an attractive route of administration to limit the issues of toxicity associated with systemic injection. We will describe here the different synthetic vectors which have been developed for the local delivery of siRNA in various organs. ... Local siRNA delivery by non-viral ...Author: F. Beilvert, F. Beilvert, M. Mével, M. Mével, B. Châtin, B. Châtin, B. Pitard, B. Pitard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453025/
The eye, brain, and tumor tissues are ‘hot’ target tissues/organs for local siRNA delivery. The siRNA can be delivered locally, in naked form, with chemical modifications, or in formulations with viral or non-viral vectors, such as liposomes and nanoparticles.Author: Meng Pan, Jinwen Ni, Huiming He, Shan Gao, Xiaohong Duan
https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Synthetic delivery vectors have the potential to address many of the limitations of viral vectors, particularly with respect to safety. For systemic delivery of DNA, both lipid-based vectors and ...Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692493/
Jun 01, 2009 · Non-viral vectors for siRNA delivery. Of primary consideration in deciding on a drug delivery system for siRNA is whether the intended disease target lends itself to systemic or local administration. In the case of delivery of DNA encoding for the short hairpin RNA (shRNA) by non-viral delivery systems, nuclear translocation of the DNA is often ...Author: Kun Gao, Leaf Huang
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/non-viral-vector
Non-viral vectors. Gene delivery based on non-viral vectors has attracted much attention due to their universal application range and high safety level of delivery. 5 A number of nanoparticle delivery systems based on polymers and liposomes have been developed. Furthermore, physical approaches including, for example, electroporation and gene ...
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