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https://www.ahajournals.org/doi/10.1161/01.CIR.0000050367.65079.71
Background— Fixed drug release kinetics and vessel wall partitioning may limit the effectiveness of drug-eluting stents. We report preliminary experience using a new coronary stent with programmable pharmacokinetics. Methods and Results— A newly designed metallic stent contains honeycombed strut elements with inlaid stacked layers of drug and polymer.Author: Ariel Finkelstein, Dougal McClean, Saibal Kar, Kaname Takizawa, Kiron Varghese, Namjin Baek, Kinam P...
https://www.ncbi.nlm.nih.gov/pubmed/12578884
Feb 11, 2003 · Local drug delivery via a coronary stent with programmable release pharmacokinetics. Finkelstein A(1), McClean D, Kar S, Takizawa K, Varghese K, Baek N, Park K, Fishbein MC, Makkar R, Litvack F, Eigler NL. Author information: (1)Division of Cardiology, Cedars-Sinai Medical Center and Department of Pathology at UCLA School of Medicine, 90048, USA.Author: Ariel Finkelstein, Dougal McClean, Saibal Kar, Kaname Takizawa, Kiron Varghese, Namjin Baek, Kinam P...
https://www.ahajournals.org/doi/pdf/10.1161/01.cir.0000050367.65079.71
Fixed drug release kinetics and vessel wall partitioning may limit the effectiveness of present drug-eluting stents.1–3 A new type of metallic stent has been engineered specifically as a next-generation coronary drug delivery system that allows precise and programmable control over spatial and temporal release kinetics and substantially en-
https://www.researchgate.net/publication/277378270_Local_Drug_Delivery_via_a_Coronary_Stent_With_Programmable_Release_Pharmacokinetics
In this study, local delivery of a hydrophobic drug from a drug-eluting stent implanted in a coronary artery is mathematically modelled to investigate the drug release and spatio-temporal drug ...
https://www.researchgate.net/publication/10907265_Local_drug_delivery_via_a_coronary_stent_with_programmable_release_pharmacokinetics
Local drug delivery via a coronary stent with programmable release pharmacokinetics. ... they convey that the magnitude of drug uptake in stent-based drug delivery is relatively insensitive to ...
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.506.1393
BibTeX @MISC{Park_localdrug, author = {Kinam Park and Michael C. Fishbein and Raj Makkar and Frank Litvack and Neal L. Eigler and Ariel Finkelstein and Dougal Mcclean and Saibal Kar and Kaname Takizawa and Kiron Varghese}, title = {Local Drug Delivery via a Coronary Stent With}, year = {}}
http://journals.lww.com/coronary-artery/pages/articleviewer.aspx?year=1999&issue=12000&article=00012&type=abstract
Coronary Artery Disease1999Background: Catheter-based local drug delivery at the site of stent implantation has been proposed to reduce in-stent restenosis. We examined whether local delivery itself may cause additional vessel wall injury and negate the potential benefit of local drug delivery in a porcine coronary in-stent restenosis model ...
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-5922.2010.00187.x
58 rows · Nov 25, 2011 · Local drug delivery (LDD), ... via vasa vasorum or small side branches, …Author: Zachary M. Gertz, Robert L. Wilensky
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390057/
Local drug-delivery balloon for proliferative occlusive in-stent restenosis after drug-eluting stent ... Drug-coated balloon has been developed as an alternative to drug-eluting stents for in-stent restenosis but the performance of drug infusion balloon in such setting has not been previously described. ... The coronary artery angiography ...Author: Gianluca Rigatelli, Paolo Cardaioli, Fabio Dell'Avvocata, Massimo Giordan
https://academic.oup.com/cardiovascres/article/35/3/405/374433
Sep 01, 1997 · From the point of view of local drug delivery, deciding on optimal therapy may require careful comparison of risk/benefit profiles between different balloon and stent delivery systems, polymer particles of different sizes and characteristics and other novel vectors to enhance delivery efficiency, and between the different vectors for gene therapy.Author: David Brieger, Eric Topol
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