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https://www.ncbi.nlm.nih.gov/pubmed/10837543
Jul 07, 1997 · Local delivery of chemotherapy: a supplement to existing cancer treatments. A case for surgical pastes and coated stents. Machan L(1), Burt HM, Hunter WL. Author information: (1)Departmental Radiology, University Hospital - UBC Site, Vancouver, BC, CanadaAuthor: William L Hunter, Helen M Burt, Helen M Burt, Lindsay Machan
https://www.sciencedirect.com/science/article/pii/S0169409X97000355
Local polymer-based delivery of chemotherapeutic agents could be easily incorporated into presently employed treatment protocols to improve efficacy and reduce the incidence of complications. Surgical pastes applied to tumor resection sites could be readily incorporated into operative procedures and combined with postoperative regional radiotherapy to reduce the incidence of local recurrence of …Author: William L Hunter, Helen M Burt, Helen M Burt, Lindsay Machan
https://cancerres.aacrjournals.org/content/56/22/5217
Nov 15, 1996 · These studies demonstrate that local delivery of chemotherapy with concurrent radiation therapy is safe and can significantly prolong survival in models of common intracranial metastatic tumors. Concurrent use of local chemotherapy with standard XRT appears to be more effective than either treatment alone.Author: Matthew Glaize Ewend, Jeffery A. Williams, Khosrow Tabassi, Betty Mae Tyler, Kelly M. Babel, Richard...
https://www.mdmag.com/journals/oncng-oncology/2009/october_2009/a_brief_review_1009
May 14, 2010 · In contrast, the CALGB trial, which compared an HAI chemotherapy regimen of FUDR, leucovorin, and dexamethasone with systemic administration of 5-FU and leucovorin, demonstrated a superior rate of response for infusional treatment at 47% versus 24% for systemic delivery. 7 The HAI treatment arm also had a greater than 4-month overall survival benefit compared with the systemic …
https://academic.oup.com/neurosurgery/article-abstract/43/5/1185/2856784
Nov 01, 1998 · Local delivery of chemotherapy in animal models directly into the CNS via implantable drug-laden polymers has been shown to provide an advantage over systemic administration of anticancer drugs (59, 63, 64). This technology makes it possible to achieve very high local concentrations of the desired cytotoxic agent without systemic toxicity and circumvents the restrictions of drug penetration …Author: Matthew G. Ewend, Matthew G. Ewend, Prakash Sampath, Jeffery A. Williams, Betty M. Tyler, Henry Brem...
http://www.noahslight.com/local-delivery-of-chemotherapy/
Local Delivery of Chemotherapy Directly into the Fourth Ventricle of the Brain: A Novel Treatment Approach for Children with Medulloblastoma and other Malignant Tumors of the Posterior Fossa. Current treatment regimens for children with malignant brain tumors include surgical resection, radiation therapy, and intravenous chemotherapy.
https://www.researchgate.net/profile/Matthew_Ewend/publication/14293949_Local_delivery_of_chemotherapy_and_concurrent_external_beam_radiotherapy_prolongs_survival_in_metastatic_brain_tumor_models/links/547261630cf24af340c533c9.pdf
These studies demonstrate that local delivery of chemotherapy with concurrent radiation therapy is safe and can significantly prolong survival in models of common intracranial metastatic tumors.
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