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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878823/
Apr 10, 2012 · Local delivery of chemotherapy could sterilize the resection margins, similarly to brachytherapy but without the radiation exposure concerns, thus reducing the incidence of locoregional tumor recurrence. The lack of local targeting by systemic chemotherapy limits its use as a means to prevent local recurrence in all patients.Author: Jesse B. Wolinsky, Yolonda L. Colson, Mark W. Grinstaff
https://www.ncbi.nlm.nih.gov/pubmed/10837543
Jul 07, 1997 · Local delivery of chemotherapy: a supplement to existing cancer treatments. A case for surgical pastes and coated stents.Author: William L Hunter, Helen M Burt, Helen M Burt, Lindsay Machan
https://www.sciencedirect.com/science/article/pii/S0169409X97000355
Local polymer-based delivery of chemotherapeutic agents could be easily incorporated into presently employed treatment protocols to improve efficacy and reduce the incidence of complications. Surgical pastes applied to tumor resection sites could be readily incorporated into operative procedures and combined with postoperative regional radiotherapy to reduce the incidence of local recurrence of …Author: William L Hunter, Helen M Burt, Helen M Burt, Lindsay Machan
https://www.mdmag.com/journals/oncng-oncology/2009/october_2009/a_brief_review_1009
May 14, 2010 · HAI chemotherapy using newer agents, such as irinotecan and oxaliplatin, are also being evaluated; however, it is likely that this chemotherapy delivery method will remain investigational because of the lack of evidence of a broad benefit, technical difficulties in administering this treatment, and the knowledge that colorectal cancer truly is a systemic disease for the vast majority of patients.
https://academic.oup.com/neurosurgery/article-abstract/43/5/1185/2856784
Nov 01, 1998 · Local delivery of chemotherapy in animal models directly into the CNS via implantable drug-laden polymers has been shown to provide an advantage over systemic administration of anticancer drugs (59, 63, 64). This technology makes it possible to achieve very high local concentrations of the desired cytotoxic agent without systemic toxicity and circumvents the restrictions of drug penetration …Author: Matthew G. Ewend, Matthew G. Ewend, Prakash Sampath, Jeffery A. Williams, Betty M. Tyler, Henry Brem...
https://www.sciencedirect.com/science/article/pii/S0928493116300625
Regional chemotherapy is used to enhance therapeutic efficiency of anticancer drugs. Local delivery of anticancer drugs reduces their toxic effects to healthy tissues. This review summarizes different approaches of local delivery of chemotherapeutics. The wide range of biomaterials used as reservoirs of anticancer drugs is described.Author: Katarzyna Krukiewicz, Jerzy K. Zak
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