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https://phys.org/news/2015-09-team-drug-delivery-lung.html
Sep 02, 2015 · Technology. Engineering. September 2, 2015 ... of lung diseases such as cystic fibrosis and airway infections by delivering pulmonary drugs using their liquid instillation ... targeted drug ...
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
ABOUT AUTHORS: Dr. N.V. Satheesh Madhav, Girish Dwivedi* Dehradun Institute of Technology, Faculty of Pharmacy Village Makkawala, Mussoorie Diversion Road, Dehradun-248009 *[email protected] ABSTRACT Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for site
https://en.wikipedia.org/wiki/Liquid_ventilation
Liquid breathing is a form of respiration in which a normally air-breathing organism breathes an oxygen-rich liquid (such as a perfluorocarbon), rather than breathing air.. This requires certain physical properties such as respiratory gas solubility, density, viscosity, vapor pressure, and lipid solubility which some, but not all, perfluorochemicals (perfluorocarbon) have.
http://www.pulmatrix.com/isperse.html
Pulmonary Dry Powder Drug Delivery Technology / PDF. ATS 2012 — A Novel Inhaled Dry Powder Delivery Platform for the Delivery of Large Molecule Drugs to the Lung for Local and Systemic Treatments / PDF. RDD Europe 2011 — iSPERSE™: Formulation and In Vitro Characterization of a Novel Dry Powder Drug Delivery Technology / PDF
http://www.aradigm.com/technologies.html
The Power Behind Effective Pulmonary Drug Delivery. ... Aradigm's AERx pulmonary drug delivery technology provides performance that is at the leading edge in terms of efficiency of delivery to the lung and reproducibility of dosing – not just in the laboratory but also as determined in many human clinical trials. ... • Liquid formulation ...
Liquidia is a late-stage clinical biopharmaceutical company focused on the development and commercialization of therapeutics using its proprietary PRINT® technology to transform the lives of patients. Currently, Liquidia is focused on the development of two product candidates using its PRINT® particle engineering platform: LIQ861 for the treatment of pulmonary arterial hypertension and ...
https://www.researchgate.net/publication/226859524_Particle_Engineering_Technologies_for_Pulmonary_Drug_Delivery
pulmonary delivery of several small molecules and peptides [5 9, 60] and have been recommended for vaccination applications [ 61 ], modulation of immune resp onses, Fig. 13.5 Schematic
https://investors.liquidia.com/news-releases/news-release-details/liquidia-submits-new-drug-application-liq861-treprostinil
Jan 27, 2020 · LIQ861 is an investigational, inhaled dry powder formulation of treprostinil designed using Liquidia’s PRINT® technology with the goal of enhancing deep-lung delivery using a convenient, palm-sized dry powder inhaler for the treatment of pulmonary arterial hypertension (PAH).
https://journals.physiology.org/doi/full/10.1152/jappl.1998.85.2.379
Relative to oral administration, pulmonary delivery exposes the administered drug to a less harsh environment, and the permeability of the alveolar epithelium is high. Compared with the sites of transdermal, nasal, vaginal, buccal, or ocular delivery, the exposed surface area of the lungs is extremely large, estimated to approximate the area of ...
https://www.azonano.com/nanotechnology-video-details.aspx?VidID=26
A pulmonary delivery device, based on surface acoustic wave technology, is being developed for the delivery of drugs such as insulin, in the form of a liquid aerosol. When the device is activated, an electric field is applied to the surface of the electrode, producing an acoustic wave.
https://www.sciencedirect.com/topics/chemistry/pulmonary-drug-delivery
For decades pulmonary drug delivery, either via pressurised metered-dose inhalers (pMDIs) or dry powder inhalers (DPIs), has been used in the topical treatment of respiratory tract diseases such as asthma (Islam and Cleary, 2012; Islam and Gladki, 2008).Yet, with advances in nanotechnology and the development of aerosol drug formulations capable of passing into the blood stream, there is ...
http://www.aradigm.com/docs/AERx%20Essence%ae%20Device%20Overview.pdf?lbisphpreq=1
AERx Essence® Pulmonary Delivery Device: ... If so, a liquid formulation may be your best option. Is limiting the cost of goods for your API important to you? If so, a liquid formulation in a very efficient pulmonary delivery system may be your best option. ... The AERx Strip technology uses the precision and speed of lasers to drill the aerosol
https://www.aarc.org/wp-content/uploads/2018/03/aersol-guides-for-hcp.pdf
adaptive aerosol delivery (AAD) technology. An AAD device monitors the patient’s breathing pattern and delivers the aerosol at the beginning of inhalation. This improves the likelihood of the aerosol penetrating deep into the respi-ratory tract. AAD nebulizers are desirable when the clini-cian prescribes a novel and/or expensive medication that
https://phys.org/news/2017-03-liquid-closer.html
Mar 14, 2017 · Liquid ventilation –breathing a liquid instead of air – has long been the stuff of science fiction, and despite experimental clinical use, its potential for treating severe pulmonary or ...
https://www.atsjournals.org/doi/full/10.1165/rcmb.2013-0479OC
Here, we introduce the Air–Liquid Interface (ALI) Cell Exposure–Cloud (ALICE-CLOUD) technology, which uses principles of cloud motion for fast and quantitative delivery of aerosolized liquid drugs to pulmonary cells cultured under realistic ALI conditions.
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