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https://www.ncbi.nlm.nih.gov/pubmed/1392538
Phospholipid vesicles (liposomes) have been widely used as a drug delivery system for standard anticancer and anti-infectious drugs. In this article we examine the potential role of liposomes as a drug delivery system for antisense oligonucleotides.Author: R.L. Juliano, Saghir Akhtar
https://www.tandfonline.com/doi/abs/10.3109/10717549609031175
The efficacy of pH-sensitive liposomes, comprising dioleoyl phosphatidyl ethanolamine, oleic acid, and cholesterol (DOPE/OA/Chol), loaded with polyrI:polyrC (polyIC), has been reported to induce interferon. This report evaluated the ability of such liposomes to deliver antisense phosphodiester oligonucleotides (ODNs).Author: Pierre G. Milhaud, Jean Pierre Bongartz, Bernard Lebleu, Jean R. Philippot
https://www.sciencedirect.com/science/article/pii/S0168365904004122
The second class of drug delivery systems are cationic liposomes which were investigated as DNA uptake enhancer before, first in gene therapy trials and consequently also in antisense studies. The first cationic lipid was introduced in 1987 by Felgner et al. [13]. Today, there are many commercial products available.Author: Jörg Weyermann, Dirk Lochmann, Andreas Zimmer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329851/
After 24 Ch cells were treated with an increasing concentration of liposomes. At the indicated time, 200 μg of blue formazan triazole (MTT) at a concentration of 4 mg/ml in PBS was added to each well and incubated for 4 h at 37°C, in 5% CO 2. Then plates were centrifuged at 4000 g, …Author: Paulina Wyrozumska, Justyna Meissner, Monika Toporkiewicz, Marta Szarawarska, Kazimierz Kuliczkowski...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposomal-drug-delivery
Liposomes, micelles, and polymer–drug conjugates are the widely explored nano drug delivery systems. The development of polymeric liposomes as drug delivery systems dates back to the 1970s [79–81]. The first FDA-approved (1995) nanopharmaceutical, Doxil [82], is based on liposomal drug delivery technology.
http://www.eurekaselect.com/133927/article?tracking-code=4
Nucleic acid based drugs (NADBs) are short DNA/RNA molecules that include among others, antisense oligonucleotides, aptamers, small interfering RNAs and mi...
https://www.sciencedirect.com/science/article/pii/S0169409X12002980
Both ‘classical’ and ‘Stealth’ liposomes have entered the mainstream as sustained release drug delivery systems [243] for the in vivo delivery of everything from small molecule therapeutics to nucleic acids. Early papers that were important in the clinical development of liposomes include a 1985 paper by Morgan et al.Author: Theresa M. Allen, Pieter R. Cullis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664895/
Oligonucleotides including antisense oligonucleotides and siRNA are emerging as promising therapeutic agents against a variety of diseases. Effective delivery of these molecules is critical to their successful clinical application. Targeted systems can greatly improve the efficiency and specificity of oligonucleotides delivery.Author: Bo Yu, Xiaobin Zhao, L. James Lee, Robert J. Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664963/
Dec 01, 2015 · Liposomes present as an attractive delivery system due to their flexible physicochemical and biophysical properties, which allow easy manipulation to address different delivery considerations. Despite considerable research in the last 50 years and the plethora of positive results in preclinical studies, the clinical translation of liposome assisted drug delivery platforms has …Author: Lisa Sercombe, Tejaswi Veerati, Tejaswi Veerati, Fatemeh Moheimani, Sherry Y. Wu, Anil K. Sood, Susa...
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