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https://www.hindawi.com/journals/jdd/2011/326497/
Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be ...Author: Daniel A. Balazs, Wt. Godbey
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066571/
Dec 15, 2010 · The liposome thus formed is a result of energetic contributions by Van der Waals forces and electrostatic binding to the DNA which partially dictates liposome shapes . Because of the polyanionic nature of DNA, cationic (and neutral) lipids are typically used for gene delivery, while the use of anionic liposomes has been fairly restricted to the ...Author: Daniel A. Balazs, Wt. Godbey
https://pubs.acs.org/doi/abs/10.1021/la400859e
Jun 27, 2013 · The success of common nonviral gene delivery vehicles, lipoplexes and polyplexes, is limited by the toxicity and instability of these charged molecules. Stealth liposomes could provide a stable, safe alternative to cationic DNA complexes for effective gene delivery. DNA encapsulations in three stealth liposomal formulations prepared by thin film, reverse phase evaporation, and asymmetric ...Author: Rachel M. Levine, Timothy R. Pearce, Maroof Adil, Efrosini Kokkoli
https://www.sciencedirect.com/science/article/pii/S0928493117304575
Jun 01, 2017 · Radwan Almofti et al. revealed that DNA-induced liposome-liposome fusion is responsible for the change in liposome size upon incorporation of DNA . The positive charge of liposomes led by amine groups of cationic lipid, DOTAP, was reduced but remained positive via incorporation of DNA, which supports the formation of liposome-DNA complexes.Author: M. Rasoulianboroujeni, G. Kupgan, F. Moghadam, M. Tahriri, A. Boughdachi, P. Khoshkenar, J.J. Ambros...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273975/
Jan 25, 2012 · Methods. Aiming to elucidate the influence of liposome/DNA charge ratio and size on transfection efficiency and on each other, we used liposome/DNA complexes with charge ratio (+/−) in the range of 1–50 and extruded through membranes of 400, 200, and 100 nm.Author: Marija Brgles, Maja Šantak, Beata Halassy, Dubravko Forcic, Jelka Tomašić
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposomal-drug-delivery
Liposomal drug delivery systems are very effective in the delivery of vaccines and genes due to their adjuvant property and targeting ability which elicit the immune response of the body through antibody formation and corrected gene inputs. Along with this, the mechanism of vaccine and gene delivery is …
http://arbutusbio.com/docs/Liposome_Formulations_Proof_for_Distribution.pdf
Liposomal Formulations for Nucleic Acid Delivery Ian MacLachlan ... LIPOSOMAL FORMULATIONS FOR NUCLEIC ACID DELIVERY 239 ... [23–26]. Fusogenic liposomes facilitate the intracellular delivery of complexed plasmid DNA by fusing with the membranes of …
https://www.nature.com/articles/nbt0797-647
Jul 01, 1997 · To increase cationic liposome-mediated intravenous DNA delivery extruded DOTAPicholesterol lipo-somes were used to form complexes with DNA, resulting in enhanced expression of the chloramphenicol ...Author: Nancy Smyth Templeton, Danilo D. Lasic, Peter M. Frederik, Helmut H. Strey, David D. Roberts, George...
https://www.researchgate.net/publication/12950633_Liposomes_as_a_gene_delivery_system
Liposomes as a gene delivery system. ... liposome-based DNA delivery systems have been described, includ-ing molecular components for targeting given cell surface receptors or.
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