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https://www.ncbi.nlm.nih.gov/pubmed/22023849
Mar 28, 2012 · Lipid based delivery systems, originating from earlier research in the fields of gene delivery, are the most studied candidates for siRNA delivery. Here we discuss the requirements that need to be met by these siRNA delivery systems to ensure adequate stability after systemic application and subsequent deposition in the target tissue.Author: Kevin Buyens, Stefaan C. De Smedt, Kevin Braeckmans, Joseph Demeester, Liesbeth Peeters, Leo A. van ...
https://www.ncbi.nlm.nih.gov/pubmed/29932659
Jul 24, 2018 · Liposome carriers for delivering small interfering RNA (siRNA) into target cells are of tremendous importance because the siRNA-based therapy offers a completely new approach for treating a wide range of diseases, including cancer and viral infections.Author: Alexandra Yu. Antipina, Andrey A. Gurtovenko, Andrey A. Gurtovenko
https://www.sciencedirect.com/science/article/pii/S0378517314005857
Co-delivery of chemotherapeutic drug and small interfering RNA (siRNA) within a nanoparticulate system will suppress the tumor growth. In the present study, docetaxel (DTX) and BCL-2 siRNA was incorporated in a PEGylated liposome to systemically deliver in a lung cancer model (A549).Author: Mei-Hua Qu, Rui-Fang Zeng, Shi Fang, Qiang-Sheng Dai, He-Ping Li, Jian-Ting Long
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30029-4
Jan 01, 2015 · The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we optimized in vitro delivery of two functional proteins, the β-galactosidase (β-gal) enzyme and the anti-cytokeratin8 (K8) antibody, using liposome-based formulation.Author: Benoît Chatin, Benoît Chatin, Mathieu Mével, Mathieu Mével, Julie Devallière, Julie Devallière, Laur...
https://onlinelibrary.wiley.com/doi/full/10.1002/art.21876
Based on these promising findings, we assessed the therapeutic efficiency of TNFα siRNA for systemic delivery in experimental arthritis, using a new liposome‐mediated formulation. In this study, we showed the effectiveness of the targeting siRNA to modulate macrophage‐derived TNFα expression at both the mRNA and protein levels in vitro.Author: Maroun Khoury, Maroun Khoury, Pascale Louis-Plence, Virginie Escriou, Danièle Noel, Céline Largeau, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006685/
DOTAP ( N - [1- (2,3-dioleoyloxy)]- N, N, N - trimethyl ammonium propane) and Oligofectamine were some of the first lipid formulations to be used for the in vivo delivery of siRNA and effective gene silencing of tumor necrosis factor α (TNF-α) and β-catenin in mice (Sorensen,...Author: Shubiao Zhang, Shubiao Zhang, Defu Zhi, Leaf Huang
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