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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/liposomal-drug-delivery
Liposomal drug delivery systems modify the kinetic and distribution of cytostatic agents leads to the increased drug release (Al-Jamal and Kostarelos, 2011; Lao et al., 2013). Liposomal drug delivery is of two types: active or triggered (Pattni et al., 2015).
https://www.sciencedirect.com/science/article/pii/S0169409X12002980
Drugs that are not weak bases, such as paclitaxel, can be converted to weak base prodrugs thus allowing encapsulation and liposomal retention . Drug release rates have important implications for the therapeutic activities of all types of drug delivery systems, including liposomes.Author: Theresa M. Allen, Pieter R. Cullis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770731/
Liposome Drug Encapsulation. Most cancer chemotherapeutic drugs also harm normal surrounding cells and tissue. These side effects can be curtailed by encapsulating these toxic drugs, such as doxorubicin in liposomes to form a “protective cage” around the drug molecules (Figure 2) (Kawakami et al. 2007).These envelopes increase circulation of drugs in the body and enable controlled release.Author: Melissa A. Tran, Rebecca J. Watts, Gavin P. Robertson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017847/
Apr 14, 2018 · 5. Influence of Liposomal Composition in Drug Delivery. Phospholipids are the main building blocks of liposomes. These biomolecules are also the main components building the biological membranes. They are amphiphilic molecules that consist of a polar head (water soluble hydroxy groups) and insoluble backbone.Author: Temidayo O. B. Olusanya, Rita Rushdi Haj Ahmad, Daniel M. Ibegbu, James R. Smith, Amal Ali Elkordy
https://mct.aacrjournals.org/content/5/7/1639
Jul 01, 2006 · Liposomes, or phospholipid vesicles, have been recognized as a potential drug delivery vehicle for three decades ([1][1]). Depending on the drug of interest, liposomes can serve as a controlled release carrier or simply as a biocompatible solubilizing vehicle for poorly soluble agents. Because ofAuthor: Robert J. Lee
https://www.naturalmedicinejournal.com/blog/secret-effective-liposomal-delivery
This is exciting, for sure, but are the claims made by all companies that offer liposomal supplements true? Not necessarily. “Liposomal delivery” is a pretty broad term and certainly not all liposome products are created equal. There are definitely key advantages with liposome products but as with anything, there are two sides of this coin.
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201901489
Interestingly, under these experimental conditions, the most potent cytotoxicity was observed for E/K‐mediated liposomal delivery of DOX. This suggests DOX delivery direct to the cell cytosol, following liposome‐cell membrane fusion, is a potentially potent method of drug delivery.Author: Li Kong, Quanchi Chen, Frederick Campbell, Ewa Snaar‐Jagalska, Alexander Kros
https://www.tandfonline.com/doi/abs/10.1517/17425247.2.3.477
May 05, 2016 · Liposomal delivery of photosensitisers will often overcome or decrease these problems. In addition, as with chemotherapeutic agents, liposomal formulations of photo-sensitising agents may help to achieve better selectivity for tumour tissue compared with normal tissue.Author: Bin Chen, Brian W Pogue, Tayyaba Hasan
https://www.uspharmacist.com/article/drug-delivery-systems-for-cancer-therapeutics
Sep 20, 2011 · Drug delivery systems, particularly liposomes, have been shown to improve the pharmacokinetic and pharmacologic parameters of conventional chemotherapeutics. In addition, response rates for some cancer types have shown improvement. Drug delivery systems also decrease the toxicity that often results from the use of chemotherapeutic agents ...
https://clincancerres.aacrjournals.org/content/clincanres/11/23/8230.full.pdf
liposomal anticancer agents with high tumor penetration and delivery of the active drug to the tumor. Modificationof Toxicity with Liposomal Agents Liposomal formulations can also modify the toxicity pro-file of a drug (e.g., Ambisome; ref. 30). This effect may be due to …Author: William C. Zamboni
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