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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374058/
Clinical application of small interfering RNA (siRNA) requires safe and efficient delivery in vivo. Here, we report the design and synthesis of lipid nanoparticles (LNPs) for siRNA delivery based on cationic lipids with multiple tertiary amines and hydrophobic linoleyl chains.Author: Bo Yu, Shu-Hao Hsu, Chenguang Zhou, Xinmei Wang, Megan C. Terp, Yun Wu, Lesheng Teng, Lesheng Teng, ...
https://www.sciencedirect.com/science/article/pii/S0142961212005042
Clinical application of small interfering RNA (siRNA) requires safe and efficient delivery in vivo. Here, we report the design and synthesis of lipid nanoparticles (LNPs) for siRNA delivery based on cationic lipids with multiple tertiary amines and hydrophobic linoleyl chains.Author: Bo Yu, Shu-Hao Hsu, Chenguang Zhou, Xinmei Wang, Megan C. Terp, Yun Wu, Lesheng Teng, Lesheng Teng, ...
https://www.researchgate.net/publication/225085585_Lipid_Nanoparticles_for_Hepatic_Delivery_of_Small_Interfering_RNA
The present study aimed to evaluate the efficiency and antitumor effect of a survivin-targeted short interfering RNA (siRNA) delivery system using lipid nanoparticles for the treatment of colon ...
https://www.sciencedirect.com/science/article/pii/S0022354917302782
The Delivery of Small Interfering RNA to Hepatic Stellate Cells Using a Lipid Nanoparticle Composed of a Vitamin A-Scaffold Lipid-Like Material. Author links open overlay panel Naoyuki Toriyabe 1 Yu Sakurai 1 Akari Kato 1 Shoshiro Yamamoto 1 Kota Tange 2 Yuta Nakai 2 …Author: Naoyuki Toriyabe, Yu Sakurai, Akari Kato, Shoshiro Yamamoto, Kota Tange, Yuta Nakai, Hidetaka Akita,...
https://www.sciencedirect.com/science/article/pii/S0928098719304324
When tumor volumes reached 10–30 mm 3 (Day 4), small interfering RNAs (siRNAs) targeting PCTAIRE1 or scramble-control with lipid nanoparticles (at a dose of 10 µg siRNAs, 0.5 mg/kg) were injected into tumors twice a week (n = 10 mice per group) using LUNAR lipid delivery technology platform. All animals were sacrificed at Day 16 after four ...Author: Deepti Parashar, Vinoth Rajendran, Ravi Shukla, Ramakrishna Sistla
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307782/
Dec 28, 2013 · Cationic lipid or lipid-like material-based nanoparticles are the most well studied nanocarriers for systemic delivery of siRNA and miRNA to the liver because of their relative safety and simplicity of production.Author: Xinmei Wang, Bo Yu, Wei Ren, Xiaokui Mo, Chenguang Zhou, Hongyan He, HuLiang Jia, Lu Wang, Samson T....
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