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https://www.sciencedirect.com/science/article/pii/S0939641103001437
Skin penetration of topically applied diclofenac is important for the treatment of rheumatic diseases and actinic keratoses. We have studied the permeation of diclofenac across human cadaver epidermis in-vitro from four lecithin vesicle formulations and a few marketed semi-solid preparations.Author: Ramesh R Boinpally, Ramesh R Boinpally, Sen-Lin Zhou, Srinivasu Poondru, Gopinath Devraj, Bhaskara R...
https://www.researchgate.net/publication/9022822_Lecithin_vesicles_for_topical_delivery_of_diclofenac
Lecithin vesicles for topical delivery of diclofenac Article in European Journal of Pharmaceutics and Biopharmaceutics 56(3):389-92 · December 2003 with 30 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352220/
Purpose: Lipid suspensions as drug carriers, including conventional liposomes, ethosomes, transferosomes, proniosomes, niosomes, PEG-PPG-PEG niosomes and stratum corneum liposomes (cerosomes), were formulated and compared. Methods: Lipid vesicles were formulated and assessed with regards to enhancement of skin permeation of diclofenac and stability profiles of the formulations.Author: Anahita Fathi-Azarbayjani, Kai Xin Ng, Yew Weng Chan, Sui Yung Chan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217704/
The interest in designing transdermal delivery systems was relaunched after the discovery of elastic vesicles like transferosomes, ethosomes, cubosomes, phytosomes, etc. This paper presents the composition, mechanisms of penetration, manufacturing and characterization methods of transferosomes as transdermal delivery systems of active substances.
https://deepblue.lib.umich.edu/bitstream/handle/2027.42/28412/0000187.pdf?sequence=1
Advanced Drug Delivery Reviews, 5 (1990) 287-300 287 Elsevier ADR 00070 Liposomes as a topical drug delivery system K. Egbaria and N. Weiner College …
https://www.hindawi.com/journals/bmri/2013/616810/
The aim of this study was to improve the transdermal permeation of Diclofenac sodium, a poorly water-soluble drug, employing conventional liposomes, ethosomes, and transfersomes. The prepared formulations had been characterized for the loaded drug amount and vesicle size. The prepared vesicular systems were incorporated into 1% Carbopol 914 gel, and a survey of <i>in vitro</i> drug release and ...Author: Saeed Ghanbarzadeh, Sanam Arami
http://europepmc.org/articles/PMC4352220
Mar 01, 2015 · Purpose: Lipid suspensions as drug carriers, including conventional liposomes, ethosomes, transferosomes, proniosomes, niosomes, PEG-PPG-PEG niosomes and stratum corneum liposomes (cerosomes), were formulated and compared. Methods: Lipid vesicles were formulated and assessed with regards to enhancement of skin permeation of diclofenac and stability profiles of the …
https://link.springer.com/article/10.1208/s12249-017-0755-8
Mar 28, 2017 · The objective of the present study was to develop and optimize generic topical gel formulation of diclofenac sodium through quality by design approaches. The quality target product profile was set for the critical quality attributes of the gel. The key material variables like hydrophilic gelling agent carbopol and penetration enhancer kolliphor were optimized using design of experiments. A ...Author: Aruna Khanolkar, Viraj Thorat, Preeti Raut, Gautam Samanta
https://link.springer.com/article/10.1208%2Fpt060240
The purpose of this review is to give an insight into the considerable potential of lecithin organogels (LOs) in the applications meant for topical drug delivery. LOs are clear, thermodynamically stable, viscoelastic, and biocompatible jelly-like phases, chiefly composed of hydrated phospholipids and appropriate organic liquid. These systems are currently of interest to the pharmaceutical ...
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