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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620406/
Oct 26, 2015 · HDL as a Drug Delivery Vehicle. The use of lipoproteins and particularly HDL (Schouten et al., 1993) as drug delivery agents was first suggested over 30 years ago (Counsell and Pohland, 1982). Subsequently, Kader and Pater (2002) evaluated HDL particles as drug transporters.Author: Andras G. Lacko, Nirupama A. Sabnis, Bhavani Nagarajan, Walter J. McConathy
https://www.unthsc.edu/graduate-school-of-biomedical-sciences/physiology-and-anatomy/physiology/lipoprotein-drug-delivery-research-laboratory/
Lipoprotein Drug Delivery Research Lab works at the interface of biochemistry, molecular biology, and material sciences. Our efforts are focused on understanding the cholesterol metabolism in cancer and use of reconstituted high-density lipoproteins (rHDL) to deliver drugs …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281595/
The most important role of LDL is the delivery of cholesterol to extrahepatic tissues for utilization in a number of processes, including steroid production and membrane synthesis (Fielding and Fielding, 1996). LDL particles have multiple distinct subspecies that differ in particle size and particle number (Berneis and Krauss, 2002).Author: Gamaleldin I. Harisa, Gamaleldin I. Harisa, Fars K. Alanazi
https://www.sciencedirect.com/science/article/pii/S0169409X16301302
Drug delivery with low density lipoprotein Low density lipoprotein is attractive as a drug delivery vehicle for both cancer and atherosclerosis due to the prevalence of the LDLr on malignant cells and the macrophages that comprise atherosclerotic plaques.Author: C. Shad Thaxton, Jonathan S. Rink, Pratap C. Naha, David P. Cormode
https://www.sciencedirect.com/science/article/pii/S0168365911010820
Although all proteins have been investigated as drug carriers, no LDL drug delivery systems have entered the clinical setting and only a few transferrin drug conjugates have entered clinical trials as drug conjugates or immunotoxins; the major clinical and commercial impact has undoubtedly been with albumin-based drug delivery systems.Author: Felix Kratz, Bakheet Elsadek
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279133/
A limited expression of LDLR will consequently result in a saturable transport capacity, thereby potentially limiting its use in brain delivery of cargo-containing nanoparticles. This implicates that drug delivery efficiency will likely be influenced by body rhythms, such as eating rhythm.Author: Julia V. Georgieva, Dick Hoekstra, Inge S. Zuhorn
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397116/
The application of synthetic lipoproteins as delivery vehicles for various molecules and agents has been diverse, ranging from delivering chemotherapeutics, antiviral and antifungal agents, to siRNAs and imaging agents. These applications offer great potential in the translation of the synthetic lipoproteins into the clinical setting.Author: Huang Huang, William Cruz, Juan Chen, Gang Zheng, Gang Zheng
https://www.nature.com/articles/s41467-019-11593-z
Aug 08, 2019 · During the past several decades, targeted drug delivery systems (TDDS) have gained increasing attention to achieve better therapeutic efficacy …Author: Zui Zhang, Juan Guan, Zhuxuan Jiang, Yang Yang, Jican Liu, Wei Hua, Ying Mao, Cheng Li, Weiyue Lu, J...
https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-2881-x
May 25, 2018 · Background. This research assesses knowledge amongst drug deliverers about the implementation of mass drug administration (MDA) for lymphatic filariasis (LF) in Agam District (West Sumatera Province), the City of Depok (West Java Province) and the City of Batam (Kepulauan Riau Province), Indonesia.
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