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https://ois.net/punctal-plugs-for-sustained-delivery/
Nov 11, 2016 · The Evolute Punctal Plug Delivery System provides sustained ocular drug delivery that “is as good or better than what’s out there,” said Bob Butchofsky, Mati Therapeutics Inc.’s chief executive officer. For sustained drug delivery devices to be successful, they must be easy to place and remove, must be cosmetically invisible but still easy to identify,…
https://clinicaltrials.gov/ct2/show/NCT01229982
A Study Evaluating the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
https://www.ophthalmologytimes.com/ophthalmology/punctal-plug-drug-delivery-attractive-method-managing-glaucoma
Punctal plug-based delivery systems for sustained delivery of glaucoma medications represent new and versatile technology that is under development. The hope is it can help with the problem of patient compliance when managing mild-moderate glaucoma, said Marlene Moster, MD.
https://clinicaltrials.gov/ct2/show/NCT00820300
Jan 12, 2009 · A Safety Study of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open Angle Glaucoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
https://eyewire.news/articles/20121025-qlt_shows_positive_efficacy_trends_from_data_in_plug_combinations_in_phase_2_studies_for_glaucoma_using_latanoprost_punctal_plug_delivery_system/
QLT Inc. announced that results from two phase 2 clinical studies, PPL GLAU 12 and PPL GLAU 13, demonstrate positive trends (with statistically and clinically significant findings) on the efficacy and safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in subjects with ocular hypertension (OH) and open-angle glaucoma (OAG).
https://bciq.biocentury.com/products/latanoprost_punctal_plug_delivery_system_(l-ppds)
QLT disclosed in its 3Q10 earnings that it began a double-blind, placebo-controlled Phase II trial to compare latanoprost punctal plug delivery system vs. Xalatan latanoprost eye drops in …
https://www.thestreet.com/investing/stocks/qlts-ceo-discusses-latanoprost-punctal-plug-delivery-system-conference-call-transcript-11278458
Oct 16, 2011 · Today’s call will review QLT’s Phase II study for glaucoma using the Latanoprost Punctal Plug Delivery System. If you have not yet received a copy of our press release, you can find it by ...
https://www.sciencedirect.com/science/article/pii/S1359644615000641
Schematic illustration of a punctal plug delivery device. The latanoprost PP delivery system (L-PPDS) was recently developed for controlled elution of latanoprost for the treatment of open-angle glaucoma (OAG) and ocular hypertension (OH).Author: Venkata K. Yellepeddi, Venkata K. Yellepeddi, Ravi Sheshala, Hannah McMillan, Chirag Gujral, David J...
https://www.aao.org/headline/latanoprost-punctal-plug-shows-good-results
QLT Inc. announced results from two phase 2 studies showing its latanoprost punctal plug delivery system lowered IOP in patients with ocular hypertension and open-angle glaucoma. In the first trial, plugs delivering a total of 141 µg or 90 µg of latanoprost were simultaneously placed in the upper and lower puncta in 57 patients.
https://www.reviewofoptometry.com/article/reinventing-glaucoma-therapy
Reinventing Glaucoma Therapy ... Mati Therapeutics has developed the Evolute (OR) punctal plug delivery system, ... Mati Therapeutics. Mati Therapeutics announces initiation of phase II study to compare latanoprost punctal plug delivery system (L-PPDS) to timolol eye drops. October 28, 2013.
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