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https://science.sciencemag.org/content/276/5320/1868.full
Jun 20, 1997 · To assess the merits of large porous particles for pulmonary drug delivery, we encapsulated model therapeutics inside porous particles (Fig. 1 A) composed of 50:50 poly(lactic acid- co -glycolic...Author: David A. Edwards, Justin S Hanes, Giovanni Caponetti, Giovanni Caponetti, Jeffrey Hrkach, Abdelaziz ...
https://www.ncbi.nlm.nih.gov/pubmed/9188534
Jun 20, 1997 · Inhalation of large porous insulin particles resulted in elevated systemic levels of insulin and suppressed systemic glucose levels for 96 hours, whereas small nonporous insulin particles had this effect for only 4 hours.Author: David A. Edwards, Justin S Hanes, Giovanni Caponetti, Giovanni Caponetti, Jeffrey Hrkach, Abdelaziz ...
https://science.sciencemag.org/content/sci/276/5320/1868.full.pdf
by virtue of their size, large particles can avoid phagocytic clearance from the lungs until the particles have delivered their therapeutic dose; this attribute can be particularly useful for controlled-release inhalation therapies. To assess the merits of large porous parti-cles for pulmonary drug delivery…Author: David A. Edwards, Justin S Hanes, Giovanni Caponetti, Giovanni Caponetti, Jeffrey Hrkach, Abdelaziz ...
https://www.researchgate.net/publication/14029607_Large_Porous_Particles_for_Pulmonary_Drug_Delivery
High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles.
http://signallake.com/innovation/EdwardsScience062097.pdf
by virtue of their size, large particles can avoid phagocytic clearance from the lungs until the particles have delivered their therapeutic dose; this attribute can be particularly useful for controlled-release inhalation therapies. To assess the merits of large porous parti-cles for pulmonary drug delivery…
https://www.academia.edu/28258866/Large_Porous_Particles_for_Pulmonary_Drug_Delivery
Large Porous Particles for Pulmonary Drug Delivery
https://www.sciencedirect.com/science/article/pii/S092809871730235X
Large porous particles (LPPs) are becoming increasingly popular as carriers for pulmonary drug delivery with both local and systemic applications (Edwards et al., 1997). These particles have high geometric diameters (5–30 μm) but low bulk density (~ 0.1 g/cm 3 or less) such that the aerodynamic diameter remains low (1–5 μm).Author: A.G. Ogienko, E.G. Bogdanova, N.A. Trofimov, S.A. Myz, A.A. Ogienko, B.A. Kolesov, A.S. Yunoshev, N....
https://www.sciencedirect.com/science/article/pii/S0168365912005433
Further, in pulmonary drug delivery, large porous particles have been reported to provide longer residence time and extended release of encapsulated drugs , . In this study, we evaluated the feasibility of encapsulating LMWH as a model drug into PEG–PLGA and PLGA–PEG–PLGA block copolymers and characterized the resulting large porous particulate formulations in vitro and in vivo.Author: Brijeshkumar Patel, Vivek Gupta, Fakhrul Ahsan
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