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https://www.sciencedirect.com/science/article/pii/S0928493111001020
Jul 20, 2011 · Investigation of swellable poly (N-isopropylacrylamide) based hydrogels for drug delivery Thermo-responsive hydrogels that can change their swelling behavior and drug release characteristics in response to environmental temperature,,,, have important applications in drug delivery …Author: G. Fu, W.O. Soboyejo
https://www.sciencedirect.com/science/article/abs/pii/S0928493111001020
The thermo-sensitive properties of poly (N-isopropylacrylamide) (PNIPA) hydrogels are modified by the addition of hydrophilic acrylamide comonomers and an interpenetrating network of sodium alginate for drug delivery applications near 37 °C.Author: G. Fu, W.O. Soboyejo
https://www.researchgate.net/publication/251619679_Investigation_of_swellable_poly_N-isopropylacrylamide_based_hydrogels_for_drug_delivery
Investigation of swellable poly (N-isopropylacrylamide) based hydrogels for drug delivery Article in Materials Science and Engineering C 31(5):1084-1090 · July 2011 with 20 Reads
https://www.sciencedirect.com/science/article/pii/S0014305715001780
The majority of thermosensitive hydrogels investigated in the past decades are synthetic polymers based on poly(N-isopropylacrylamide) (PNIPA) , , . PNIPA hydrogels exhibit a non-linear volume phase transition (VPT) at a lower critical solution temperature (LCST) around 34 °C, which is close to the natural temperature of the human body [3] , [5] .Author: Enikő Manek, Attila Domján, János Madarász, Krisztina László
https://www.mdpi.com/2073-4360/12/3/580
Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies ...Author: Xiaomin Xu, Yang Liu, Wenbo Fu, Mingyu Yao, Zhen Ding, Jiaming Xuan, Dongxiang Li, Shengjie Wang, Yo...
https://pubs.acs.org/doi/abs/10.1021/mz200121k
Degradable, covalently in situ gelling analogues of thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) hydrogels have been designed by mixing aldehyde and hydrazide-functionalized PNIPAM oligomers with molecular weights below the renal cutoff. Co-extrusion of the reactive polymer solutions through a double-barreled syringe facilitates rapid gel formation within seconds. The resulting ...Author: Mathew Patenaude, Todd Hoare
http://onlinelibrary.wiley.com/doi/10.1002/app.35644/abstract
Mar 08, 2012 · Experiments on drug release from the crosslinked NIPAM-co-MAc hydrogel loaded with ibuprofen into different pH buffer solutions were successfully carried out at temperature swing between 25 and 40°C.
https://link.springer.com/article/10.1007%2Fs00289-018-2526-4
Sep 19, 2018 · Smart hydrogels comprising guar gum (GG) and poly(N-isopropylacrylamide) (PNIPAAm) cross-linked using a non-toxic cross-linker, tetraethyl orthosilicate, have been designed to explore the sustained release of an anticancer drug, 5-fluorouracil (5FU).Hydrogels containing preformed solid inclusion complexes (IC) of 5FU in β-cyclodextrin (β-CD) were designed to regulate the drug delivery.Author: Subhraseema Das, Usharani Subuddhi
https://www.sciencedirect.com/science/article/pii/S0032386108000487
For example, poly(N-isopropylacrylamide)-block-poly(methyl methacrylate) micelles entrapped inside a poly(N-isopropylacrylamide) hydrogel can release prednisone acetate in a controlled manner according to the temperature of the thermosensitive hydrogel network . 4. Expanding the range of drugs amenable to hydrogel-based deliveryAuthor: Todd R. Hoare, Daniel S. Kohane
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