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https://www.sciencedirect.com/science/article/pii/S0378517319308129
Research of intravitreal drug delivery systems (DDSs) stems from the need to minimise repeated intravitreal injections of anti-VEGF antibodies, which thereof will decrease the risk of adverse effects and will optimise the public economic expense that these patients require.Author: Andrea Luaces-Rodríguez, Andrea Luaces-Rodríguez, Cristina Mondelo-García, Irene Zarra-Ferro, Miguel...
http://www.medicalpolicy.hcsc.net/medicalpolicy/archivePolicyPage?lid=ht6gjdnx&
An intravitreal implant is a drug delivery system, surgically implanted in the vitreous of the eye, for sustained release of a drug to the posterior eye segment. A fluocinolone acetonide intravitreal implant (Retisert®; Bausch and Lomb, Rochester, N.Y.) is commercially available for the treatment of noninfectious posterior uveitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010371/
Jun 18, 2018 · Intravitreal, periocular, subretinal, and systemic drug delivery systems all have their advantages and drawbacks. The nanotechnology-based delivery systems used in those routes offer promising alternatives for overcoming the limitations of the frequent and long-term intravitreal injection.Author: Sibo Jiang, Yesenia L Franco, Yan Zhou, Jianjun Chen
http://retinatoday.com/2010/04/a-novel-sustainedrelease-intravitreal-drug-delivery-system-for-retinal-vascular-disease
The Verisome technology is a robust drug-delivery system that, according to its manufacturer, can potentially be used to release a broad range of pharmaceutical agents, including small molecules, peptides, proteins, and monoclonal antibodies.
https://www.liebertpub.com/doi/abs/10.1089/108076801753162807
The delivery of drugs to the retina from solution or from prolonged release forms is considered in terms of pharmacokinetics, interference with vision, and toxicity and safety. It is concluded that visual loss will be the limiting factor in determining the useful life of a drug administered as a microdispersion.Author: David Maurice
https://www.researchgate.net/publication/259724480_Tunable_sustained_intravitreal_drug_delivery_system_for_daunorubicin_using_oxidized_porous_silicon
Our ultimate goal in d eveloping a sustained intraocular delivery system is to keep the therapeutic drug level at the disease site for seve ral months or longer to reduce the eye injection ...
https://www.retinalphysician.com/issues/2004/august-2004/intravitreal-injections-a-coding-and-reimbursemen
Aug 01, 2004 · These hold a great deal of promise for avoiding the pain and infection possible with intravitreal injections. CPT 67027 describes implantation of intravitreal drug delivery system and includes concomitant removal of vitreous. The reimbursement climate for …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Periocular drug delivery using the transscleral absorption pathway is one of the safest means of achieving consistent therapeutic drug concentrations in the inner coat of the posterior segment (Table 1). 5,6,24 Periocular drug delivery systems, however, require drugs to pass through several layers of ocular tissue (episclera, sclera, choroid, Bruch's membrane, and RPE) to reach the retina or vitreous …Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
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