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https://neurosurgery.directory/2019/04/05/intrathecal-drug-delivery-device-infection/
Apr 13, 2019 · Intrathecal Drug Delivery Device Infection A major complication of Intrathecal Drug Delivery Device (IDDD) implantationis infection. Morgalla et al., assessed IDD-related complications in 51 patients who had IDD systems implanted for the treatment of chronic pain or spasticity. Twelve patients (23.5%) presented a total of 22 complications. The main type of complication was catheter-related (50 ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227625/
Nov 06, 2014 · Advances in intrathecal analgesia and intrathecal drug delivery systems have allowed for a range of medications to be used in the control of pain and spasticity. This technique allows for reduced medication doses that can decrease the side effects typically associated with …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761861/
Jan 29, 2016 · Intrathecal drug delivery systems can be used to manage refractory or persistent chronic nonmalignant (noncancer) pain. We investigated the benefits, harms, cost-effectiveness, and budget impact of these systems compared with current standards of care ...
http://www.britishpainsociety.org/static/uploads/resources/files/itdd_2015_pro_v3.pdf
4 Intrathecal drug delivery for the management of pain and spasticity in adults; Introduction and purpose The technique of intrathecal drug delivery (ITDD) is based on the principle that effective analgesia can be achieved by the action of some drugs at the dorsal horn where …
https://en.wiktionary.org/wiki/intrathecal
Feb 17, 2019 · intrathecal (not comparable) Delivered into the spinal canal (intrathecal space surrounding the spinal cord), e.g. a spinal anesthesia. Translations .
https://www.sciencedirect.com/science/article/pii/S0163725814001041
Intrathecal delivery of protein therapeutics to the brain: A critical reassessment. ... Here, we review blood–brain barrier functions and cerebrospinal fluid dynamics and their relevance to drug delivery via the intrathecal route, discuss animal and human studies that have investigated intrathecal delivery of protein therapeutics, and outline ...Author: Pericles Calias, William A. Banks, David Begley, Maurizio Scarpa, Patricia Dickson
https://academic.oup.com/bjaed/article/14/1/27/336442
Sep 04, 2013 · Intrathecal drug delivery (ITDD) systems comprise an IT catheter connected to a drug reservoir, which may be externalized and connected to a pump, or fully implanted. Two groups of patients may benefit from ITDD: those with spasticity (baclofen) and those with refractory pain.Author: Louise Lynch
https://medicine.utah.edu/pmr/conference/files/2012/R.Penn-Intrathecal%20Drug%20Therapies%20-%20Saturday.pdf
CNS Drug Delivery . First Patient Intrathecal Baclofen 1984 . Why IT Delivery Works Avoids the blood brain barriers High local spinal concentration . Key to Understanding Intrathecal Delivery REGIONAL DISTRIBUTION VERY SLOW KINETICS OF DISTRIBUTION ... Intrathecal Drug Delivery ...
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